At least two genetically distinct glucose transporters (GTs) coexist in adipose cells, one cloned from human hepatoma cells and rat brain (HepG2/brain) and another from rat skeletal muscle, heart, and adipose cells (adipose cell/muscle). Here we demonstrate differential regulation of these two GTs in adipose cells of diabetic and insulin-treated diabetic rats and compare changes in the expressi...

Background/Aims Serotonin receptor (eg, 5-HT₃) antagonists are used to treat nausea and vomiting from a variety of causes. Granisetron transdermal system (GTS) is an appealing delivery system for patients with gastroparesis. To assess if GTS improves nausea and vomiting and other gastroparesis symptoms in patients with gastroparesis. Methods Patients with gastroparesis and symptoms of nausea ...

BACKGROUND HCV affects 185 million people worldwide and leads to death and morbidities. HCV has a high genetic diversity and is classified into seven genotypes and 67 subtypes. Novel anti-HCV drugs (Direct-Acting-Antivirals) eligibility, resistance and cure rates depend on HCV geno/subtype (GT). OBJECTIVES Analysis of epidemiological information and viral GT from patients undergoing viral gen...

The current IEEE 802.15.4 standard restricts the beacon enabled approach to star networks, while they support multi-hop networking in mesh but with no synchronization. In this paper there is proposal of a distributed IEEE802.15.4 MAC modification to improve GTS usability in cluster networks. Location of BOP in inactive period with Virtual GTS is proposed and throughput is observed for chain top...

The Gilles de la Tourette syndrome (GTS) is a neurobehavioural disorder characterized by multiple motor and vocal tics. Accessory symptoms include coprophenomena, echophenomena and obsessive-compulsive behaviours. There is a significant genetic contribution to their aetiology. Simple tics may be mistaken for myoclonic epilepsy and complex tics for complex partial seizures. Like epilepsy, GTS is...

Amino acids were found to play an integral role in modulating glucose-induced desensitization of the glucose transport system (GTS). When adipocytes were treated for 6 h in a defined buffer containing 25 ng/ml insulin, 20 mM glucose, plus the 15 amino acids found in Dulbecco's modified Eagle's medium, we observed marked desensitization of the GTS, manifested by a 60% decrease in maximal insulin...

Glycosyltransferases (GTs), the enzymes that catalyse glycosidic bond formation, create a diverse range of saccharides and glycoconjugates in nature. Understanding GTs at the molecular level, through structural and kinetic studies, is important for gaining insights into their function. In addition, this understanding can help identify those enzymes which are involved in diseases, or that could ...

a7 Nicotinic receptors are calcium permeant and provide neuroprotection against many insults. We investigated the roles of intracellular calcium ions and downstream calcium channels in this protection. The a7 agonist GTS-21 prevented pheochromocytoma cell death induced by nerve growth factor + serum deprivation over a 3-day interval. This effect was blocked by the intracellular calcium chelator...

The IEEE 802.15.4 Medium Access Control (MAC) protocol is an enabling standard for wireless sensor networks. In order to support applications requiring dedicated bandwidth or bounded delay, it provides a reservation-based scheme named Guaranteed Time Slot (GTS). However, the GTS scheme presents some drawbacks, such as inefficient bandwidth utilization and support to a maximum of only seven devi...

By using the representational power of Chu spaces we define the notion of a generalized topological space (or GTS, for short), i.e., a mathematical structure that generalizes the notion of a topological space. We demonstrate that these topological spaces have as special cases known topological spaces. Furthermore, we develop the various topological notions and concepts for GTS. Moreover, since ...