نتایج جستجو برای: gsk3b
تعداد نتایج: 241 فیلتر نتایج به سال:
Genetic polymorphisms are often considered as risk factors of complex diseases serving as valuable and easily detectable biomarkers, also stable during the whole lifespan. A novel type of genetic polymorphism has been identified just recently, referred to as gene copy number variation (CNV) or copy number polymorphism. CNV of glycogen synthase kinase 3 beta and its adjacent gene, Nr1i2 (pregnan...
Purpose: Prescriptions of Han-Shi-Yu-Fei (HSYF), Han-Shi-Zu-Fei (HSZF), and Yi-Du-Bi-Fei (YDBF) were effective in treating COVID-19. Based on network pharmacology molecular docking, overlapping Traditional Chinese medicines (TCMs), their active components, core targets explored this study. Methods: First, the TCMs components collected from Medicine Systems Pharmacology Database Analysis Platfor...
Purpose: Bone defects caused by injuries, trauma, cancer, surgical operation or joint dislocation have great impacts on general health. Considering that Wnt signalling is one of the important regulators of the stem cell control, we sought to examine if Wnt activation affects the osteogenic differentiation of the USSCs.Materials and Methods: In this study, we have treated USSCs cultured in osteo...
Critical for the maintenance of epidermal stability and function are attachments between intermediate filaments (IF) intercellular junctions called desmosomes. The desmosomal cytoplasmic plaque protein desmoplakin (DP) is essential anchoring IF to junction. DP-IF interactions regulated by a phospho-regulatory motif within DP C-terminus. Previously we showed that hypo-phosphorylated increased in...
Background: Periodontal disease(s) and metabolic illnesses negatively impact the quality of life and, eventually mental health. Objective: This study investigated effect Porphyromonas gingivalis (W83) oral infection on development Alzheimer’s disease (AD) pathophysiology in a wild-type obese, diabetic (db/db) mouse model. Methods: The db/db mice were either orally infected with P. Fusobacterium...
Although alcohol effects within the liver have been extensively studied, the complex mechanisms by which alcohol causes liver cancer are not well understood. It has been suggested that ethanol (EtOH) metabolism promotes tumor growth by increasing hepatocyte proliferation. In this study, we developed a mouse model of tumor promotion by chronic EtOH consumption in which EtOH feeding began 46 days...
We recently demonstrated that obinutuzumab (GA101), a novel glycoengineered type II CD20 Ab compared to rituximab (RTX) mediates significantly enhanced antibody-dependent cell cytotoxicity (ADCC) in vitro and increased overall survival in a Burkitt lymphoma (BL) xenograft non-obese diabetic severe combined immunodeficiency gamma (NSG) model. In this study we compared the phosphoproteomic change...
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