نتایج جستجو برای: gsi
تعداد نتایج: 2631 فیلتر نتایج به سال:
Further evidence for the predicted repulsive K nucleon potential in nuclear matter New data from the KAOS spectrometer at GSI reveal an azimuthally anisotropic distribution of K mesons in relativistic gold-gold collisions. In peripheral and semi-central collisions, K mesons are preferentially emitted perpendicular to the reaction plane. The results are consistent with the theoretical prediction...
Abstract Background: The process of medical education is stressful and medical students are at risk of psychological problems. In addition to the normal stressors of everyday life, medical students must deal with stresses specific to medical school. The aim of this study was to assess mental health in senior medical students and residents. Methods: This cross-sectional study included 100 senio...
UNLABELLED Next-generation sequencing was used to identify Notch mutations in a large collection of diverse solid tumors. NOTCH1 and NOTCH2 rearrangements leading to constitutive receptor activation were confined to triple-negative breast cancers (TNBC; 6 of 66 tumors). TNBC cell lines with NOTCH1 rearrangements associated with high levels of activated NOTCH1 (N1-ICD) were sensitive to the gamm...
Cancer stem cells (CSC) are associated with tumor resistance and are characterized in gastric cancer (GC). Studies have indicated that Notch and wnt-beta-catenin pathways are crucial for CSC development. Using CD44+ CSCs, we investigated the role of these pathways in GC carcinogenesis. We performed cell proliferation, wound healing, invasion, tumorsphere, and apoptosis assays. Immunoblot analys...
Clues to Alzheimer disease (AD) pathogenesis come from a variety of different sources including studies of clinical and neuropathological features, biomarkers, genomics and animal and cellular models. An important role for amyloid precursor protein (APP) and its processing has emerged and considerable interest has been directed at the hypothesis that Aβ peptides induce changes central to pathog...
Genetic stock identification (GSI) using molecular markers is an important tool for management of migratory species. Here, we tested a cost-effective alternative to individual genotyping, known as allelotyping, for identification of highly informative SNPs for accurate genetic stock identification. We estimated allele frequencies of 2880 SNPs from DNA pools of 23 Atlantic salmon populations usi...
Introduction In the past, thin uranium fluoride targets in the form of UF4 on carbon backings were applied for heavy-ion experiments repeatedly. With this compound targets we had several problems: UF4 had to be evaporated on thick carbon substrates of about 45 μg/cm2. The targets were mechanically very fragile and showed heavy sputtering in the beam. The durability of the targets upon irradiati...
Constitutive Notch activation is required for the proliferation of a subgroup of T-cell acute lymphoblastic leukemia (T-ALL). Downstream pathways that transmit pro-oncogenic signals are not well characterized. To identify these pathways, protein microarrays were used to profile the phosphorylation state of 108 epitopes on 82 distinct signaling proteins in a panel of 13 T-cell leukemia cell line...
PURPOSE To determine whether uveal melanoma, the most common primary intraocular malignancy in adults, requires Notch activity for growth and metastasis. EXPERIMENTAL DESIGN Expression of Notch pathway members was characterized in primary tumor samples and in cell lines, along with the effects of Notch inhibition or activation on tumor growth and invasion. RESULTS Notch receptors, ligands, ...
According to the American Journal of Radiology, more than half of small lesions—particularly those found in the abdomen region that includes the kidney, liver, and lung—are indeterminate by conventional CT exams. As a result, additional testing, such as a PET or MR scan, may be required to make a definitive diagnosis, possibly resulting in unnecessary healthcare costs and patient anxiety. It’s ...
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