OBJECTIVE An adverse intrauterine environment indicated by both low birth weight and monozygosity is associated with an age- or time-dependent reduction in glucose disposal and nonoxidative glucose metabolism in twins, suggesting impaired regulation of muscle glycogen synthesis. RESEARCH DESIGN AND METHODS We measured the activities of glycogen synthase (GS), GS kinase (GSK)3 alpha, GS phosph...

We studied small bowel biopsy specimens with architecturally normal villi from 78 adult patients with potential gluten sensitivity (GS) and correlated them with outcome to characterize morphologic features that would allow a pathologist to suggest GS. No patient had a previous GS diagnosis. Twelve study patients had GS. The mean number of intraepithelial lymphocytes (IELs) per 20 enterocytes fr...

Purpose: To investigate whether tumor volume derived from apparent diffusion coefficient (ADC)maps (VolumeADC) and tumormeanADCvalue (ADCmean) are independent predictors of prostate tumorGleason score (GS). Experimental Design: Tumor volume andGSwere recorded fromwhole-mount histopathology for 131 men (median age, 60 years) who underwent endorectal diffusion-weightedMRI for local staging of pro...

High-molecular-weight glutenin subunits (HMW-GS) composition was analyzed by sodium-dodecyl-sulfatpolyacrilamid-gel electrophoresis (SDS-PAGE), while the quantitative determination of total HMW-GS was obtained by reversed phasehigh performance liquid chromatography (RP-HPLC). Considering HMW-GS composition, the most frequent subunits at Glu-A1 locus were N, at Glu-B1 locus 7+9 and at Glu-D1 loc...

OBJECTIVES Surgery residency serves 2 purposes-prepare graduates for general surgery (GS) practice or postresidency surgical fellowship, leading to specialty surgical practice (SS). This study was undertaken to elucidate factors influencing career choice for these 2 groups. METHODS All US allopathic surgery residency graduates from 2009 to 2013 (n = 5512) were surveyed by the American Board o...

PURPOSE We evaluated oncologic outcomes following radical prostatectomy (RP) in patients with a Gleason score (GS) of 7 with tertiary Gleason pattern 5 (TGP5). MATERIALS AND METHODS We retrospectively reviewed the medical records of 310 patients who underwent RP from 2005 to 2010. Twenty-four patients who received neoadjuvant or adjuvant antiandrogen deprivation or radiation therapy were excl...

Glutamine synthetase (GS) is the key enzyme in ammonia assimilation and catalyzes the ATP-dependent condensation of NH3 with glutamate to produce glutamine. GS in plants is an octameric enzyme. Recent work from our laboratory suggests that GS activity in plants may be regulated at the level of protein turnover (S.J. Temple, T.J. Knight, P.J. Unkefer, C. Sengupta-Gopalan [1993] Mol Gen Genet 236...

Tonya ha s a b i g ma th t e s t t omor r ow and sh e n e ed s t o s t udy t on i gh t . W hi l e a t t h e g r o c e r y s t o r e s h e s e e s a Ginkgo B i l oba ad v e r t i s emen t t ha t c l a ims i t w i l l imp r o v e h e r memo r y. B e c au s e s h e wan t s t o d o w e l l o n h e r t e s t , s h e buy s t h e Ginkgo B i l oba , g o e s h ome , and r e v i ew s t h e s ame ma th sh...

The v ideo games deve loped 20 yea r s ago had s imp le g r aph i c s and we ren’t ve r y r e a l i s t i c . However , new v ideo games a r e qu i t e complex , and they c an de p i c t r e a l i s t i c v io l en t s c enes. Many non-v io l en t v ideo games ex i s t ( such a s some spor t s games ) . However , the mos t f r equen t l y u sed g ames a r e the v io l en t ones. Effects of Viol...

BACKGROUND Weak grip strength (GS) is a key component of sarcopenia and frailty and a powerful predictor of mortality, morbidity and disability. Despite increasing interest in understanding GS across the lifespan, little is known about GS decline in the very old (aged ≥85). We examined trajectories of GS in very old adults and identified the determinants. METHODS GS (kg) was measured four tim...