The interaction of human growth hormone with human lymphocytes from an established culture (IM-9) was studied using lz51-human growth hormone. The binding of l*51human growth hormone was rapid; with human growth hormone at 0.1 no a steady state was observed in 90 min at 30”. Bound labeled human growth hormone was dissociated rapidly by addition of excess unlabeled human growth hormone. Binding ...

introduction: breast cancer is the most common malignancy with more than one million new cases diagnosed annually all around the world. its growth is mostly regulated by steroid hormones such as estrogen and peptide growth factors in interaction with epidermal growth factor 1 and 2. methods and materials: in this study, 237 patients who had consulted the oncology clinic of tabriz university of ...

In some individuals with autosomal dominant isolated growth hormone deficiency, one copy of growth hormone lacks amino acids 32-71 and is severely misfolded. We transfected COS7 cells with either wild-type human growth hormone or Delta 32-71 growth hormone and investigated subcellular localization of growth hormone and other proteins. Delta 32-71 growth hormone was retained in the endoplasmic r...