نتایج جستجو برای: group ii phospholipases a2

تعداد نتایج: 1517520  

Journal: :Journal of Histochemistry & Cytochemistry 1997

Journal: :Neoplasia 2008
Mario Menschikowski Albert Hagelgans Heike Kostka Graeme Eisenhofer Gabriele Siegert

Epigenetic changes provide a frequent mechanism for transcriptional silencing of genes in cancer cells. We previously established that epigenetic mechanisms are important for control of group IIA phospholipase A(2) (PLA2G2A) gene transcription in human DU-145 prostate cells. In this study, we analyzed the involvement of such mechanisms in the regulation of five sPLA(2) isozymes and the M-type r...

Journal: :Circulation. Cardiovascular genetics 2015
Montse Guardiola Holly J Exeter Claire Perret Lasse Folkersen Ferdinand Van't Hooft Per Eriksson Anders Franco-Cereceda Gabrielle Paulsson-Berne Jutta Palmen KaWah Li Jackie A Cooper Kay-Tee Khaw Ziad Mallat Ewa Ninio Sonia-Athina Karabina Steve E Humphries S Matthijs Boekholdt Michael V Holmes Philippa J Talmud

BACKGROUND Observational studies report that secretory phospholipase A2 (sPLA2) activity is a marker for coronary heart disease (CHD) risk, and activity measures are thought to represent the composite activity of sPLA2-IIA, -V, and -X. The aim of this study was to use genetic variants of PLA2G10, encoding sPLA2-X, to investigate the contribution of sPLA2-X to the measure of sPLA2 activity and c...

2014
Dan Yang Hong-Fei Ji Xue-Mei Zhang Hui Yue Lin Lin Yu-Yan Ma Xiang-nan Huang Jin Fu Wei-Zhi Wang

Cytosolic phospholipase A2 (cPLA2) is the rate-limiting enzyme that initiates the production of various inflammatory mediators. Previous studies have shown that inhibiting cPLA2 exerts a neuroprotective effect on experimental autoimmune encephalomyelitis (EAE) by ameliorating the severity of the disease and influencing Th1 and Th17 responses. However, it remains unclear whether treatment with a...

Journal: :The Biochemical journal 1999
J Cheng J J Baldassare D M Raben

Addition of alpha-thrombin to quiescent IIC9 cells results in the activation of lipid-metabolizing enzymes associated with signal-transduction cascades. These enzymes include phosphatidylinositol (PI)-specific phospholipase C (PI-PLC), phosphatidylcholine (PC)-specific phospholipases C and D and phospholipase A2 (PLA2). Whereas the alpha-thrombin receptor has been shown to couple with PI-PLCs, ...

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