The aim of this contribution is to examine the impact incorporating surfactants into amorphous solid dispersions on state miscibility and aqueous solubility antifungal drug griseofulvin. Spray dried griseofulvin (GF) hypromellose acetate succinate (HPMCAS) were prepared by spray drying. Three different varying ratios between 1 5% used namely anionic sodium dodecyl sulfate (SDS), cationic dodecy...

Objective: Validation of analysis method is important, especially in analyzing narrow-index drugs such as warfarin (WF). This study aimed to obtain a validated human plasma according European Medicine Agency guidelines.
 Methods: The optimum conditions for the using fluorescence detector HPLC with Chiralcel OD-RH column (4.6 x 150 mm i.d., 5μm); guard (4.0 10 mm, 5μm), temperature 45 °C. m...

The antifungal activities of itraconazole, ketoconazole, fluconazole, terbinafine and griseofulvin were tested by broth microdilution methods against 71 isolates of dermatophytes isolated from Nigerian children. Most drugs were very active against all the dermatophytes and the MIC 90 ranged from 0.03 to 8.0 microg/mL. This appears to be the first documented data on the antifungal susceptibility...