Objective: Simple, rapid RP-HPLC and HPTLC methods have been developed in order to study the degradation of Roxadustat under various stress conditions. The Kinetics hydrolytic is studied. Methods: Optimum separation its products was achieved using following conditions HPLC, Agilent eclipse XDB-C8 (150×4.6 mm) column, mobile phase composed methanol: phosphate buffer (pH 5, 0.05 M) (70:30 v/v) wi...

Development and Validation of RP-HPLC Method for the Simultaneous Estimation Domperidone Naproxen in Tablet Dosage FormMd. Shozan Mondal, Md. Ahsanul Haque, Mohammad Safiqul Islam, S.M. Ashraful Islam

Development and Validation of RP-HPLC Method for the Simultaneous Estimation Domperidone Naproxen in Tablet Dosage FormMd. Shozan Mondal, Md. Ahsanul Haque, Mohammad Safiqul Islam, S.M. Ashraful Islam

Development and Validation of RP-HPLC Method for the Simultaneous Estimation Domperidone Naproxen in Tablet Dosage FormMd. Shozan Mondal, Md. Ahsanul Haque, Mohammad Safiqul Islam, S.M. Ashraful Islam

We present a rapid, sensitive, and automated HPLC method with direct resolution of l-folinic acid (l-FA), d-folinic acid (d-FA), and 5-methyltetrahydrofolate (5MTHF) from plasma samples. Plasma (500 microL) is first extracted on solid phase (RP-18 cartridge). The dI-FA peak is collected on-line from a reversed-phase column (RP-8, 119 x 2 mm, 4 microns: HPLC 1) and then automatically loaded onto...

A large body of evidence highlights that propolis exerts many biological functions that can be ascribed to its antioxidant and anti-inflammatory components, including different polyphenol classes. Nevertheless, the molecular mechanisms are yet unknown. The aim of this study is to investigate the mechanisms at the basis of propolis anti-inflammatory and antioxidant activities. The effects of two...