Fatigue is recognized as one of the most disabling and frequent symptoms of multiple sclerosis (MS). Amantadine appears to have some proven ability to alleviate the fatigue in MS. The aim of this study was to assess the efficacy of co-administration of amantadine and aspirin for the treatment of fatigue in multiple sclerosis. Forty-five ambulatory patients aged 20–50 years with a diagnosis of M...

Greater peripheral quadriceps fatigue at the voluntary termination of single-leg knee-extensor exercise (KE), compared with whole-body cycling, has been attributed to confining group III and IV skeletal muscle afferent feedback to a small muscle mass, enabling the central nervous system (CNS) to tolerate greater peripheral fatigue. However, as task specificity and vastly differing systemic chal...

Abstract. Verbs may be attributed to higher agency than other grammatical categories. In Study 1, we confirmed this hypothesis with archival datasets comprising verbs ( N = 950) and adjectives 2115). We then investigated whether (vs. adjectives) increase message effectiveness. three experiments presenting potential NGOs (Studies 2 3) or corporate campaigns (Study 4) in verb adjective form, demo...

BACKGROUND Fatigue in combination with gait and balance impairments can severely limit daily activities in people with multiple sclerosis (PWMS). Generalised fatigue has a major impact on walking ability, with moderately disabled PWMS experiencing difficulty in walking extended distances. Localised motor fatigue in the ankle dorsiflexors can lead to foot drop, further reducing functional ambula...

OBJECTIVES To examine the frequency and correlates of fatigue and its impact on physical and social functioning in patients with scleroderma, and to investigate whether fatigue mediates an association between pain and physical function. METHODS One hundred and seven scleroderma patients attending an academic scleroderma specialty centre completed measures of fatigue, sleep, pain, depressive s...