In vitro and in vivo laboratory data show that pomegranate juice consistently inhibits intestinal CYP2C9 and CYP3A4 enzymes. Pomegranate juice may therefore increase the bioavailability of drugs that are metabolized by these enzymes. However, studies in humans find that pomegranate juice does not increase exposure to either CYP2C9 or CYP3A4 substrates. These contradictory findings suggest that ...

This article presents studies to determine the acute toxicity and cumulative activity of polyphenolic powders derived from pomegranate peel grape seed. When administered intragastrically mice in doses 500 2000 mg/kg, no was detected, animal death observed, deviations norm other external parameters were observed. The study preparations (PPPP) seed (PPGS) showed that they belong V class chemical ...

Colon cancer is one of the major causes of cancer-related death in the Western world. Although cytotoxic chemotherapeutic agents are available to treat the disease, these agents become ineffective as the disease advances to an invasive state. An alternative but viable approach to reduce the incidence of this deadly disease is then, to increase the dietary intake of relatively non-toxic fruits a...

Abstract Aim. The present study was carried out to evaluate the wound healing potential of crude Hydroalcoholic fruit extracts Grape ( Vitis vinifera L.) and Pomegranate Punica granatum in experimental animals. Material methods. Extracts were formulated as ointments (250 mg), their properties determined by using two models: i.e. excision burn models, rabbits. Wound assessed measuring rate contr...

to evaluate the nutritive value in some lignocellulosic materials, 3 sets of experiments were conducted on aspen, and grape woods. to enhance the digestibility, the woods were treated with 5% naoh. throughout the first trial, chemical composition and digestibility coefficients of dry matter, organic matter and ndf of experimental feeds, ph of rumen, as well as palatability were evaluated while ...

oral allergy syndrome (oas) is occasionally observed following consumption  of raw fruits  in  allergic adults. since this  phenomenon  was  commonly  reported  in  khorasan province of iran; we intended to check if common  diagnostic tests could be applied for differential diagnosis of oas to grapes. ige reactivity of 84 patients with oas to grape and 34 patients with oas to other fruits were ...

ABSTRACT - Vermicomposting with pomegranate pulp can not only prevent pollution of the environment but can also create jobs, generate added value and prevent the waste of energy and the country's capital. This factorial experiment was conducted in a completely randomized design. The first factor (a) in two levels contained neutralized pomegranate pulp with lime and non-neutralized pulp. The sec...

BACKGROUND Oxidative stress plays an important role in the pathogenesis of bleomycin-induced lung fibrosis and many antioxidant agents have been used for the treatment of this disease in animals. OBJECTIVES To evaluate the antioxidant effects of pomegranate seed extract (PSE) on bleomycin treated rats. MATERIALS AND METHODS Male Spraque - Dawley rats were divided into 5 groups: rats in grou...

Patients and methods A 26 year old female patient developed erythema, swelling of the ears and pruritus within 10 min after ingestion of pomegranate. She is allergic to birch pollen and apple. Prick and IgE tests revealed a positive reaction to mites, tree and grass pollen, ambrosia, mugwort and apple. Scratch test was positive for pomegranate, the seeds showing a stronger reaction than the jui...