Tissue-specific extracellular matrix plays an important role in promoting tissue regeneration and repair. We hypothesized that decellularized annular fibrosus matrix may be an appropriate scaffold for annular fibrosus tissue engineering. We aimed to determine the optimal decellularization method suitable for annular fibrosus. Annular fibrosus tissue was treated with 3 different protocols with T...

BACKGROUND Solitary cysticercus granuloma and single parenchymal calcified lesion are two common neuroimaging abnormalities in Indian patients with epilepsy. In this study, we evaluated the frequency and predictors of seizure recurrence in patients presenting with new onset epilepsy or single epileptic seizures and these two different imaging findings. MATERIALS AND METHODS We enrolled 115 pa...

introduction basidiobolomycosis is a rare disease that, unlike other fungal infections, affects immunocompetent individuals. it is caused by an environmental saprophyte named the fungus basidiobolus ranarum. basidiobolomycosis usually appears as a subcutaneous infection. gi basidiobolomycosis is an emerging disease, and the colon is the most frequent involved part of the gi tract. case presenta...

purpose : to report two cases of orbitofrontal cholesterol granuloma, which is a rare progressive destructive disease case reports : we report two patients with orbitofrontal cholesterol granuloma a 50-year-old man and a 20-year-old woman both with progressive proptosis due to a cystic lesion in the superior part of the orbit with frontal bone erosion and intracranial extension. the second case...

Manasse was first reported cholesterol granuloma of the middle ear in 1917. Shambaugh in 1929 described idiopathoc hemotympanum as a cause to the development of cholesterol granuloma of middle ear. Cholesterol granuloma have been seen in multiple area of the human body where cholesterol crystals may exist such as the lungs, breasts, peritoneum, mediastinum, liver, spleen, thyroid, kidneys, lymp...

Multiple immune factors control host responses to Mycobacterium tuberculosis infection, including the formation of granulomas, which are aggregates of immune cells whose function may reflect success or failure of the host to contain infection. One such factor is TNF-α. TNF-α has been experimentally characterized to have the following activities in M. tuberculosis infection: macrophage activatio...

Granuloma annulare is a benign inflammatory skin lesion of unknown etiology that is usually seen in adults and children and subtypes of it includes localized granuloma annulare, generalized granuloma annulare, subcutaneous granuloma annulare and arcuate dermal erythema. Etiology and pathogenesis of granuloma annulare are obscure, although there is much evidence for an immunologic mechanism. Pre...

Definition Pyogenic granuloma (PG) is a common reactive neoformation of the oral cavity, which is composed of granulation tissue and develops in response to local irritation or trauma. Various different names have been given to this entity, reflecting, in part, mistaken concepts about its aetiopathogenesis: • Botryomycosis hominis • Botryomycoma • Telangiectatic granuloma • Benign pedunculated ...

Granuloma formation and its regulation are dependent on lymphocytes. Therefore, we compared the characteristics of lymphocytes derived from the spleens and granulomas of Schistosoma mansoni-infected mice during the course of their disease. We examined lymphocyte cell cycle kinetics, migration, expression of activation Ags (CD69 and IL-2R), cytokine production (IL-2, IL-4, IFN-gamma), and apopto...