Left-handed gold nanoparticle double helices were prepared using a new method that allows simultaneous synthesis and assembly of discrete nanoparticles. This method involves coupling the processes of peptide self-assembly of and peptide-based biomineralization of nanoparticles. In this study, AYSSGAPPMPPF (PEPAu), an oligopeptide with an affinity for gold surfaces, was modified with an aliphati...

Layer-by-layer films comprised of alternating graphene and gold nanoparticle layers are readily produced by the two-step procedure involving the use of vacuum filtration of a reduced graphene oxide solution to fabricate the graphene thin film on the quartz substrate, followed by gold nanoparticle formation by spontaneous reduction of gold ions in a gold salt solution on the graphene films.

Molecular dynamics simulation has been performed to analyze the effect of the presence of gold nanoparticle on dynamics of Kob-Anderson binary Lennard-Jones (BLJ) mixture upon supercooling within the framework of the mode coupling theory of the dynamic glass transition. The presence of gold nanoparticle has a direct effect on the liquid structure and causes the peaks of the radial distribution ...

Human cytomegalovirus (CMV) is a herpesvirus that causes major health problems in neonates as well as in immunocompromised individuals. At present, a vaccine is not available for CMV infection and the available antiviral drugs suffer from toxicity, poor efficacy and resistance. Here, we chemically conjugated a monoclonal antibody raised against CMV surface glycoprotein (gB) with gold nanopartic...

Gold nanoparticles modified with the nuclear localization signal from simian virus 40 large T antigen (GNP-PEG/SV40) accumulate on the cytoplasmic side of the nuclear membrane in HeLa cells. Accumulation of GNP-PEG/SV40 around the nucleus blocks nucleocytoplasmic transport and prevents RNA export and nuclear shuttling of signaling proteins. This long-term blockage of nucleocytoplasmic transport...

BACKGROUND Unique properties exhibited by nanoparticles makes them great candidates for applications in physics, chemistry, biology, material science and medicine. The biological applications of water-soluble gold nanoparticles range from contrast agents, delivery vehicles to therapeutics. Notch signaling is a complex network that orchestrates cell fate decisions, which involves proliferation, ...

This study describes smart Cu(II)-aptamer complexes based gold nanoplatform for tumor micro-environment triggered programmable prodrug release, in demand photodynamic therapy and aggregation induced photothermal ablation of hepatocellular carcinoma. The nanoplatform is consist of monodispersed gold nanoparticle (GNP) that is binding to HCC cell specific targeting aptamers (TLS11a) through Au-S ...

  Introduction: In the present study, we investigated the role of gold-silica shell-core nanoparticle in megavoltage irradiation of MCF7 breast cancer cells.   Materials and Methods: gold-silicon oxide shell-core nanoparticles (NPs) were obtained by conjugation of gold nanoparticle with amine or thiol functionalized silica nanoparticles (AuN@SiO2 and AuS@SiO...

Gold nanoparticle assemblies possess diverse application potential, ranging from industrial nanotechnology to medical biotechnology. Because the structures and properties of assemblies are directly affected by the stabilization mechanism between the organic molecules serving as protecting ligands and the gold nanoparticle surface, it is crucial to find and investigate new stabilization mechanis...

in this paper, we have described the size-controlled synthesis of gold nanoparticles based on the reduction of au3+ (haucl4 ) using molybdophosphoric acid (h3[pmo12o40 ], hpmo) under uv-irradiation. in the process, hpmo plays the role of photocatalyst, reducing agent and stabilizer and propan-2-ol acts as a sacrificial agent. this method allows the synthesis of uniform hexagonal nanoparticles w...