Analyses of rare events occurring at extremely low frequencies in body fluids are still challenging. We established a versatile microarray-based platform able to capture single target cells from large background populations. As use case we chose the challenging application of detecting circulating tumor cells (CTCs)--about one cell in a billion normal blood cells. After incubation with an antib...

Cow’s milk protein allergy (CMPA) is a common condition present in approximately 2-7.5% of children. The diagnosis is usually made in the first 12 months of life by taking a thorough clinical history and by performing confirmatory special investigations. These may include skin-prick tests, blood tests and an oral food challenge, which remains the gold standard investigation. Allergic reactions ...

Consumers’ views of genetically modified foods (GM foods) can influence food producers’ decisions as to whether to market GM foods or whether to use conventional varieties. Through labelling, supported by certification, consumers could differentiate a GM food from a conventional food. A working group of the Codex Committee on Food Labelling identified seven approaches to labelling of GM foods. ...

We propose a method for labelling prepositional phrases according to two different semantic role classifications, as contained in the Penn treebank and the CoNLL 2004 Semantic Role Labelling data set. Our results illustrate the difficulties in determining preposition semantics, but also demonstrate the potential for PP semantic role labelling to improve the performance of a holistic semantic ro...

We apply the methods developed in [Br1] to study holomorphic functions of slow growth on coverings of pseudoconvex domains in Stein manifolds. In particular, we extend and strengthen certain results of Gromov, Henkin and Shubin [GHS] on holomorphic L2 functions on coverings of pseudoconvex manifolds in the case of coverings of Stein manifolds.

This paper presents a strategy for matching features in multiple images, which emphasises reliable matching and the recovery of feature extraction errors. The process starts from initial ‘good’ matches, which are validated in multiple images using multi-image constraints. These initial matches are then filtered through a relaxation procedure and are subsequently used to locally predict addition...

The lack of contextual integrity in region labelling schemes for segmented visual images has been a long standing problem in computer vision. In the past it has been common to adopt some form of relaxation scheme, such as relaxation labelling, to remove both labelling ambiguities and labellings which, usually, are obviously contextually incorrect. So far no general region labelling system has b...

We prove an analog of the classical Hartogs extension theorem for CR L2 functions defined on boundaries of certain (possibly unbounded) domains on coverings of strongly pseudoconvex manifolds. Our result is related to a question formulated in the paper of Gromov, Henkin and Shubin [GHS] on holomorphic L2 functions on coverings of pseudoconvex manifolds.