In this paper we present a technique aimed for simultaneous detection of multiple types of gold nanoparticles (GNPs) within a biological sample, using lock-in detection. We image the sample using a number of modulated laser beams that correspond to the number of GNP species that label a given sample. The final image where the GNPs are spatially separated is obtained computationally. The propose...

In the developing cerebellar cortex, granule neuron precursors (GNPs) proliferate and commence differentiation in a superficial zone, the external granule layer (EGL). The molecular basis of the transition from proliferating precursors to immature differentiating neurons remains unknown. Notch signaling is an evolutionarily conserved pathway regulating the differentiation of precursor cells of ...

Introduction: Radiation therapy is an important procedure for treatment of more than half of tumors. One way to increase the efficiency of radiation therapy is application of radiosensitizer at the site of tumor. gold nanoparticles (GNPs) have several characteristics that make them attractive for using with radiation therapy including small size (1–100 nm), biocompatibility, pr...

The surface parameter of nanoparticles such as hydrophobicity and a hydrophilicity on protein structure and function is very important. In this study, conformational changes of glucose oxidase (GOx) in the mercaptopurine: GNPs and 11-mercaptoundecanoic acid: GNPs as a hydrophobic and a hydrophilic GNPs surface was investigated by various spectroscopic techniques, including: UV-Vis absorption, f...

Introduction: Hyperthermia created by microwave (MW), infrared, ultrasound and other methods, is often utilized as an adjuvant to sensitize cancer cells to the effects of chemotherapy and radiation therapy. We investigated the efficacy of hyperthermia using MW in synergy with chemotherapy in the presence and absence and gold nanoparticles (GNPs). Material and Methods: After culturing and prolif...

In this study the influence of dicarboxy acetone (DCA), as an oxidation product of sodium citrate, was evaluated by ‘reversed Turkevich’ method in this study. Gold nanoparticles (GNPs) were synthesized systematically at various sodium citrate to HAuCl4 molar ratio and temperature. TheseThe GNPs were characterized by UV-vis spectroscopy, DLS and TEM techniques. The results showed that by reversi...

We present a method of enhanced laser thermal ablation of HepG2 cells based on a simple gold nanoparticle (GNP) carrier system such as serum albumin (Alb), and demonstrate its selective therapeutic efficacy compared with normal hepatocyte cells. HepG2 or hepatocytes were treated with Alb-GNPs at various concentrations and various incubation times, and further irradiated using a 2 W, 808 nm lase...

Despite major advances in the field of radiotherapy, healthy tissue damage continues to constrain the dose that can be prescribed in cancer therapy. Gold nanoparticles (GNPs) have been proposed as a solution to minimize radiation-associated toxicities by enhancing the radiation dose delivered locally to tumor cells. In the current study, we investigated the application of third-generation GNPs ...