The 'glycine tolerance test', an oral dose of glycine followed by analysis of peripheral blood samples, was first used for investigating amino acid absorption more than 30 years ago by Heath and Fullerton (1935), who, though they did not investigate any cases of unequivocal malabsorption, concluded that the test gave 'no useful information regarding the rate of absorption from the gastrointesti...

Recent work has slhown that treatment of plants with 2,4-dichlorophenoxyacetic acid (2,4-D) results in a reduction of carbohydrate and an accumulation of nitrogen (2, 10, 13, 14, 15). SELL et al. (14) and WELLER et al. (16) have observed differences in carbohydrate, nitrogen, and amino acid content that occur primarily in the proliferated stem tissue of the red kidney bean plants. LUECKE et al....

1 describes the design, synthesis and operation of an artificial small-molecule capable of synthesizing peptides in a sequence-specific manner. The design of this artificial molecular machine was, in the author's own words, " inspired by the ribosome " ; 2 with several elements analogous to ribosomal protein synthesis (Fig. 1). The tRNA's of conventional translation are substituted by amino aci...

A novel staphylolytic enzyme, ALE-1, is a glycylglycine endopeptidase produced by Staphylococcus capitis EPK1. ALE-1 possesses seven histidines. Chemical modification studies using diethylpyrocarbonate and iodoacetic acid suggested that a histidine or tyrosine residue(s) in the molecule is important for the organism's staphylolytic activity. All of the histidine residues, one tyrosine, and one ...

The anterior nares are a primary ecologic niche for Staphylococcus aureus, and nasal colonization by this opportunistic pathogen increases the risk of development of S. aureus infection. Clearance of S. aureus nasal colonization greatly reduces this risk. Mupirocin ointment is the current standard of care for clearance of S. aureus nasal colonization, but resistance to this antibiotic is emergi...

Earlier studies1' 2 of electron spin resonance of free radicals produced by ionizing irradiations in proteins revealed two characteristic patterns which occur for many different kinds of proteins at room temperatures, usually separately but sometimes in combination. One of these patterns is a doublet like that observed for irradiated acetylglycine, glycylglycine, and certain other peptides.1' 3...