AIMS To investigate the associations of HbA1c, fasting glucose, and postload plasma glucose with 10-year fatal and non-fatal cardiovascular disease (CVD) and all-cause mortality in Caucasian individuals between 50 and 75 years of age without diabetes. METHOD AND RESULTS The 10-year risk of all-cause mortality and CVD in relation to HbA1cand glucose levels was assessed with Cox survival analys...

INTRODUCTION This study aimed to determine if data mining methodologies could identify reproducible predictors of dapagliflozin-specific treatment response in the phase 3 clinical program dataset. METHODS Baseline and early treatment response variables were selected and data mining used to identify/rank all variables associated with reduction in glycated hemoglobin (HbA1c) at week 26. General...

In October 2015 we published the paper 'Measurement of HbA1c in multicentre diabetes trials - should blood samples be tested locally or sent to a central laboratory: an agreement analysis'. Chatterjee and Pradhan have submitted a letter to the editor asking critical questions regarding the methods we used. We offer this letter in response. TRIAL REGISTRATION Eudract No. 2010-023792-25. Regist...

OBJECTIVE mHealth interventions have the potential to facilitate self-management. This TEXT4DSM study implemented a mobile phone intervention in existing diabetes programmes in three low- and middle-income countries (Democratic Republic of Congo, Cambodia, and the Philippines). RESEARCH DESIGN AND METHODS Sub-studies with a similar randomised controlled trial design were conducted in three di...

OBJECTIVE To determine whether glucose-independent differences in HbA1c exist between people of African, South Asian, and Chinese ethnicities. RESEARCH DESIGN AND METHODS Data from 6,701 people aged 19-78 years, without known diabetes, from Mauritius, and participating in the population-based Non-Communicable Disease Surveys of the main island and the island of Rodrigues were included. Partic...

The issue of when and how to initiate insulin in type 2 diabetes is one that has engendered much debate (1). Some recent evidence may aid in this discussion. First, the desirable glycemic targets are largely agreed upon, with only a few minor disagreements (2,3). Data from the U.K. Prospective Diabetes Study (UKPDS) and the Diabetes Control and Complications Trial (DCCT) have demonstrated a str...

OBJECTIVE To evaluate socioeconomic disadvantage in prevalence, awareness and control of diabetes in universal coverage healthcare system. METHODS Data from the fifth KNHNES (2010-12) were analyzed. The sample included 10,208 individuals with diabetes aged ≥30 years. Diabetes was defined by (i) a self-reported previous diagnosis of diabetes made by a physician, (ii) the current use of oral hy...

OBJECTIVE The objective of this study was to evaluate the impact of a problem-based empowerment patient education program specifically tailored for urban African Americans with type 2 diabetes. RESEARCH DESIGN AND METHODS The study used a randomized controlled trial (RCT) pretest/post-test design with repeated measures. Patients were randomly assigned to either a six-week intervention group o...

OBJECTIVE To determine if a laboratory data report (the HbA1c Tracking Tool) could be used as an effective intervention to improve diabetes management. DESIGN A longitudinal quasi-experimental cohort design was used to test the effectiveness of an HbA1c summary report sent to primary care physicians for all patients having HbA1c levels greater than 7%. SETTING Moncton, New Brunswick, Canada...

OBJECTIVE To evaluate differences in HbA1c concentrations between centers and to assess the factors associated with glycemic control in young people with type 1 diabetes in Scotland. RESEARCH DESIGN AND METHODS Data on 1,755 patients (94% of those registered) were collected from 18 centers providing care to children <15 years of age. At every clinic visit, a duplicate HbA1c sample was measure...