نتایج جستجو برای: glycogen synthase kinase 3 beta gsk3beta

تعداد نتایج: 2182371  

Journal: :The Journal of biological chemistry 1985
D T Chu H Shikama B S Khatra J H Exton

The effects of hypothyroidism on glycogen metabolism in rat skeletal muscle were studied using the perfused rat hindlimb preparation. Three weeks after propylthiouracil treatment, serum thyroxine was undetectable and muscle glycogen and Glc-6-P were decreased. Basal and epinephrine-stimulated phosphorylase a and phosphorylase b kinase activities were also significantly reduced, as were epinephr...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Jae-Woo Kim Qi-Qun Tang Xi Li M Daniel Lane

CCAAT enhancer binding protein beta (C/EBPbeta) plays an essential role in the cascade that triggers adipocyte differentiation. C/EBPbeta activates transcription of C/EBPalpha and peroxisome proliferator-activated receptor-gamma, transcriptional activators of genes that give rise to the adipocyte phenotype. Sequential phosphorylation of C/EBPbeta/liver activating protein (LAP) on Thr(188) by MA...

Journal: :Cancer research 2008
Roberta Venè Patrizia Larghero Giuseppe Arena Michael B Sporn Adriana Albini Francesca Tosetti

The induction of programmed cell death in premalignant or malignant cancer cells by chemopreventive agents could be a valuable tool to control prostate cancer initiation and progression. In this work, we present evidence that the C-28 methyl ester of the synthetic oleanane triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO-Me) induces cell death in androgen-responsive and unre...

Journal: :Wiley Interdisciplinary Reviews: RNA 2018

2013
Chad A. Bousman Stephen J. Glatt Sharon D. Chandler James Lohr William S. Kremen Ming T. Tsuang Ian P. Everall

Genes in the Wnt (wingless)/ β -catenin signaling pathway have been implicated in schizophrenia pathogenesis. No study has examined this pathway in the broader context of psychosis symptom severity. We investigated the association between symptom severity scores and expression of 25 Wnt pathway genes in blood from 19 psychotic patients. Significant correlations between negative symptom scores a...

2015
Yuki Yoshino Chikashi Ishioka

Glycogen synthase kinase-3 beta (GSK-3β) has been investigated as a therapeutic target for numerous human diseases including cancer because of their diverse cellular functions. Although GSK-3β inhibitors have been investigated as anticancer reagents, precise biological mechanisms remain to be determined. In this study, we investigated the anticancer effects of GSK-3β inhibitors on cancer cell l...

Journal: :The Journal of Cell Biology 2005
Kathleen A. Ryan Sanjay W. Pimplikar

Amyloid precursor protein (APP), implicated in Alzheimer's disease, is a trans-membrane protein of undetermined function. APP is cleaved by gamma-secretase that releases the APP intracellular domain (AICD) in the cytoplasm. In vitro studies have implicated AICD in cell signaling and transcriptional regulation, but its biologic relevance has been uncertain and its in vivo function has not been e...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
W Timothy O'Brien Amber DeAra Harper Fernando Jové James R Woodgett Silvia Maretto Stefano Piccolo Peter S Klein

Lithium is widely used to treat bipolar disorder, but its mechanism of action in this disorder is unknown. Several molecular targets of lithium have been identified, but these putative targets have not been shown to be responsible for the behavioral effects of lithium in vivo. A robust model for the effects of chronic lithium on behavior in mice would greatly facilitate the characterization of ...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2005
Isabelle Plante Daniel G Cyr Michel Charbonneau

Overexpression of the integrin-linked kinase (ILK) pathway disrupts cell-cell interactions, an epigenetic event leading to epithelial cell transformation. Female rats exposed to hexachlorobenzene (HCB) for 5 consecutive days and sampled 45 days later show a decrease in liver gap junctional intercellular communication. We hypothesized that HCB also alters E-cadherin expression and that this alte...

Journal: :Neuron 2006
Woo-Yang Kim Feng-Quan Zhou Jiang Zhou Yukako Yokota Yan-Min Wang Takeshi Yoshimura Kozo Kaibuchi James R. Woodgett E. S. Anton William D. Snider

Glycogen synthase kinase-3beta (GSK-3beta) is thought to mediate morphological responses to a variety of extracellular signals. Surprisingly, we found no gross morphological deficits in nervous system development in GSK-3beta null mice. We therefore designed an shRNA that targeted both GSK-3 isoforms. Strong knockdown of both GSK-3alpha and beta markedly reduced axon growth in dissociated cultu...

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