نتایج جستجو برای: glycine rich loop

تعداد نتایج: 311334  

Journal: :Cancer research 1970
R K Wilson W C Starbuck C W Taylor J Jordan H Busch

Journal: :Neuroscience 2015
A Naito K H Muchhala J Trang L Asatryan J R Trudell G E Homanics R L Alkana D L Davies

We recently developed ultra-sensitive ethanol receptors (USERs) as a novel tool for investigation of single receptor subunit populations sensitized to extremely low ethanol concentrations that do not affect other receptors in the nervous system. To this end, we found that mutations within the extracellular Loop 2 region of glycine receptors (GlyRs) and γ-aminobutyric acid type A receptors (GABA...

Journal: :Molecular pharmacology 2000
K R Aubrey A D Mitrovic R J Vandenberg

In the central nervous system, glycine is a coagonist with glutamate at the N-methyl-D-aspartate subtype of ionotropic glutamate receptors. The GLYT1b subtype of glycine transporters is expressed in similar regions of the brain as the excitatory N-methyl-D-aspartate receptors and has been postulated to regulate glycine concentrations within excitatory synapses. We have expressed GLYT1b in Xenop...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Natascha Schaefer Christoph J Kluck Kerry L Price Heike Meiselbach Nadine Vornberger Stephan Schwarzinger Stephanie Hartmann Georg Langlhofer Solveig Schulz Nadja Schlegel Knut Brockmann Bryan Lynch Cord-Michael Becker Sarah C R Lummis Carmen Villmann

Recent studies on the pathogenic mechanisms of recessive hyperekplexia indicate disturbances in glycine receptor (GlyR) α1 biogenesis. Here, we examine the properties of a range of novel glycine receptor mutants identified in human hyperekplexia patients using expression in transfected cell lines and primary neurons. All of the novel mutants localized in the large extracellular domain of the Gl...

Journal: :The Journal of biological chemistry 2005
Rebecca Hawthorne Joseph W Lynch

The external loop linking the M2 and M3 transmembrane domains is crucial for coupling agonist binding to channel gating in the glycine receptor chloride channel (GlyR). A substituted cysteine accessibility scan previously showed that glycine activation increased the surface accessibility of 6 contiguous residues (Arg271-Lys276) toward the N-terminal end of the homomeric alpha1 GlyR M2-M3 loop. ...

Journal: :Biophysical journal 2014
Aurélie Gouron Anne Milet Helene Jamet

Casein kinase CK2 is an essential enzyme in higher organisms, catalyzing the transfer of the γ phosphate from ATP to serine and threonine residues on protein substrates. In a number of animal tumors, CK2 activity has been shown to escape normal cellular control, making it a potential target for cancer therapy. Several crystal structures of human CK2 have been published with different conformati...

Journal: :Molecular pharmacology 2016
Carlos F Burgos Gonzalo E Yévenes Luis G Aguayo

Glycine receptors (GlyR) are inhibitory Cys-loop ion channels that contribute to the control of excitability along the central nervous system (CNS). GlyR are found in the spinal cord and brain stem, and more recently they were reported in higher regions of the CNS such as the hippocampus and nucleus accumbens. GlyR are involved in motor coordination, respiratory rhythms, pain transmission, and ...

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