OBJECTIVE To test whether adding mobile application coaching and patient/provider web portals to community primary care compared with standard diabetes management would reduce glycated hemoglobin levels in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS A cluster-randomized clinical trial, the Mobile Diabetes Intervention Study, randomly assigned 26 primary care practices to one of...

OBJECTIVES Development and validation of a direct enzymatic HbA1c assay that utilizes a single channel on chemistry auto-analyzers without the need to run separate glycated hemoglobin and total hemoglobin assays. DESIGN AND METHODS An enzyme based single channel assay was developed to measure %HbA1c in human whole blood samples. The performance characteristics of the Diazyme Direct Enzymatic ...

Intraindividual variation (CVi) for glycohemoglobin (GHb) was estimated from serial measurements in patients with diabetes in either stable or variable clinical control. GHb determinations were performed by an affinity column procedure with an analytical imprecision of 4.9% (weighted average; GHb 8.2-14.7%). Within the groups of patients, both a short- (28-32 days) and long-term (approximately ...

Background: Given the high prevalence of type II diabetes and its complications, the evidence regarding the beneficial effects of probiotic yogurt on some cardiovascular biomarkers in diabetic patients is worthy of investigation. Aim: To investigate the effect of probiotic yogurt on blood glucose level and cardiovascular biomarkers in patients with type II diabetes. Method:This randomized, clin...

Fructosamine measurement, on the other hand, exploits the ability of serum proteins to undergo glycation (glycosylation) in conditions of increased ambient glycemia. Glycated proteins are an accepted measure of intermediate glycemia2,3 as demonstrated by the well established clinical usage of hemoglobin A determinations. Serum proteins are glycated as well, and determinationlc of their values r...

of Glycohemoglobin by 14 Analytical Methods, SeungTae Lee, Cas W. Weykamp, Yong-Wha Lee, Jong-Won Kim, 1 and Chang-Seok Ki ( Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 2 Department of Clinical Chemistry, Queen Beatrix Hospital, Winterswijk, The Netherlands; 3 Department of Laboratory Medicine and Genetics, So...