Cancer is regarded as one of the world's most serious health issues. Glucose regulated protein (GRP78) exhibits a vital role in proliferation, invasion, and metastasis numerous cancer cells. Based on that, this study screened 390 natural compounds targeting GRP78 catalytic site. Among them, corynanthin, toyocamycin, nanaomycin were found to strongly bind with possess binding affinities -8.4, -8...

The SNF3 gene is required for high-affinity glucose transport in the yeast Saccharomyces cerevisiae and has also been implicated in control of gene expression by glucose repression. We report here the nucleotide sequence of the cloned SNF3 gene. The predicted amino acid sequence shows that SNF3 encodes a 97-kilodalton protein that is homologous to mammalian glucose transporters and has 12 putat...

Visceral Leishmaniasis (VL) is a disease of poor and neglected populations; it affects 79 countries of the world and accounts 58,000 new cases to each year. However, no effective treatment for cure of the disease is yet available. Therefore, the present study was designed to assess the curative efficacy of single dose of sodium stibogluconate in combination with Killed Leishmania donovani (KLD)...

Genes homologous to heat shock protein 70 have been described in parasitic protozoa. It has been proposed that they may be important to the parasite as it moves from the vertebrate host at 37 degrees C to the insect. We now describe a genomic DNA clone isolated from Plasmodium falciparum that encodes a protein similar in sequence to a mammalian heat shock-related protein, the 78-kDa glucose-reg...

Introduction Introduction: Data from the CEO database shows microRNA (miR) -28-3p levels are elevated in diabetic patients. Nevertheless, role of miR-28-3p peripheral artery disease with diabetes have not been investigated. Material and methods The level miR-28-3p, CXXC5, CXXC-type zinc finger protein 5, CXXC5’s downstream molecules as well endothelial function were Dual luciferase analyses use...