نتایج جستجو برای: glucose homeostasis
تعداد نتایج: 249489 فیلتر نتایج به سال:
Alskär, O. 2018. Mechanism-Based Modelling of Clinical and Preclinical Studies of Glucose Homeostasis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 248. 62 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0247-8. Glucose is an important nutrient and energy source in the body. However, too high concentration in the blood is harmful and may lea...
Glucose homeostasis is of paramount concern to the brain since glucose is its primary fuel. Thus, the brain has evolved mechanisms to sense and respond to changes in glucose levels. The efferent aspects of the central nervous system response to hypoglycemia are relatively well understood. In addition, it is accepted that the brain regulates food intake and energy balance. Obesity and diabetes b...
Introduction: A specific role of dopamine D2 receptor signaling of midbrain and hypothalamic dopaminergic systems has not been yet identified in energy homeostasis. Here, we investigated effects of intra-ventromedial hypothalamus (VMH) administration of the D2 receptor agonist (quinpirole) and antagonist (sulpiride) on plasma leptin and glucose levels in fasted rats. Methods: A guide cannul...
Background: Glucokinase serves as a glucose sensor in pancreatic β-cells and plays a key role in glucose homeostasis and glucose-stimulated insulin secretion (GSIS). In the present study we examined the effect of glucosamine, a glucokinase inhibitor, on the pancreatic glucokinase and hexokinase activities and on insulin secretion from freshly rat pancreatic islets of Langerhans. Insulin concen...
background leptin and adiponectin are two hormones, which are released from adipocytes in order to control energy expenditure. both hormones are also involved in glucose homeostasis through control of insulin secretion from pancreatic islets. since pdx1, pparγ, and foxm1 play important roles in islets function, it is essential to understand how these genes are regulated in the islets of langerh...
The present research study was designed to evaluate the effect of zinc supplementation on body weight, serum triglyceride, cholesterol, glucose homeostasis, oxidative stress, and hepatic function in mice. Mice were treated with sulphate at an equivalent weight 6.5 mg/kg-body elemental for four weeks. Bodyweight, glucose, MDA, nitric oxide, vitamin C, enzymes level determined end period. Data fr...
OBJECTIVE AMP-activated protein kinase (AMPK) signaling acts as a sensor of nutrients and hormones in the hypothalamus, thereby regulating whole-body energy homeostasis. Deletion of Ampkα2 in pro-opiomelanocortin (POMC) neurons causes obesity and defective neuronal glucose sensing. LKB1, the Peutz-Jeghers syndrome gene product, and Ca(2+)-calmodulin-dependent protein kinase kinase β (CaMKKβ) ar...
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