نتایج جستجو برای: gliomas
تعداد نتایج: 10988 فیلتر نتایج به سال:
Objective(s): The study objective was to assess the diagnostic performance of positron emission tomography (PET) for gliomas using the novel tracer 18F-fluciclovine (anti-[18F]FACBC) and to evaluate the safety of this tracer in patients with clinically suspected gliomas.Methods: Anti-[18F]FACBC was administered to 40 patients with clinically suspected high- or low-grade gliomas, followed by PET...
Background & Objective: Gliomas are the most common type of primary intracranial tumors in adults. The expression of estrogen receptors varies in different grades of glial tumors, and some studies have suggested that this expression might have a prognostic value. It seems that estrogen receptor expression negatively correlates with the histological grade of gliomas. In the pres...
Gliomas are a heterogeneous group of cancers that predominantly arise from glial cells in the brain, but may also neural stem cells, encompassing low-grade glioma and high-grade glioblastoma. Whereas better diagnosis new treatments have improved patient survival for many cancers, glioblastomas remain challenging with highly unfavorable prognosis. This review discusses super-family enzymes, 2-ox...
In the present study, important parameters like frequency distribution of Gliomas, age group Glioma patients, common sex involved, commonest site occurrence, clinical presentations, radiological histopathological correlation, p16INK4a expression glial tumors are compared with other similar studies. The aim is to find out occurrence and it includes higher grades Astrocytomas. study focuses on sy...
Background: Artificial intelligence (AI) models provide advanced applications to many scientific areas, including the prediction of pathologic grade tumors, utilizing radiology techniques. Gliomas are among malignant brain tumors in human adults, and their efficient diagnosis is high clinical significance. Objectives: Given contribution AI medical diagnoses, we investigated role deep learning d...
Background: The most common primary tumors of brain are gliomas. Grading of tumor is vital for designing proper treatment plans. The gold standard choice to determine the grade of glial tumor is biopsy which is an invasive method.Objective: In this study, we try to investigate the role of fractional anisotropy (diffusion anisotropy) and linear anisotropy ...
BACKGROUND Glioblastoma multiforme (GBM), a high-grade glioma, is characterized by being diffuse, invasive, and highly angiogenic and has a very poor prognosis. Identification of new biomarkers could help in the further diagnosis of GBM. OBJECTIVE To identify ELTD1 (epidermal growth factor, latrophilin, and 7 transmembrane domain-containing protein 1 on chromosome 1) as a putative glioma-asso...
In 1890, Coley observed that cancer patients who developed infections had smaller tumors. From this, he developed Coley’s toxin and treated tumors with injections of infectious materials. In 1960s, Mahaley used monoclonal antibodies to treat central nervous system(CNS) tumors, that research and clinical investigations in brain tumor immunotherapy became a serious undertaking. ...
The glutamate exchanger xCT (SLC7a11) is causally linked with the malignancy grade of brain tumors and represents a key player in glutamate, cystine and glutathione metabolism. Although blocking xCT is not cytotoxic for brain tumors, xCT inhibition disrupts the neurodegenerative and microenvironment-toxifying activity of gliomas. Here, we report on the use of various xCT inhibitors as single mo...
Low-grade gliomas are one of the most common brain tumors in children, where they frequently form within the optic pathway (optic pathway gliomas; OPGs). Since many OPGs occur in the context of the Neurofibromatosis Type 1 (NF1) cancer predisposition syndrome, we have previously employed Nf1 genetically-engineered mouse (GEM) strains to study the pathogenesis of these low-grade glial neoplasms....
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