نتایج جستجو برای: gk model

تعداد نتایج: 2106445  

Journal: :International journal of experimental diabetes research 2001
Thomas L. Jetton Masa Shiota Susan M. Knobel David W. Piston Alan D. Cherrington Mark A. Magnuson

Hepatic glucokinase (GK) is acutely regulated by binding to its nuclear-anchored regulatory protein (GKRP). Although GK release by GKRP is tightly coupled to the rate of glycogen synthesis, the nature of this association is obscure. To gain insight into this coupling mechanism under physiological stimulating conditions in primary rat hepatocytes, we analyzed the subcellular distribution of GK a...

2015
Ezarul Faradianna Lokman Harvest F. Gu Wan Nazaimoon Wan Mohamud Claes-Göran Östenson

Aims. To evaluate the antidiabetic effects of Gynostemma pentaphyllum (GP) in Goto-Kakizaki (GK) rat, an animal model of type 2 diabetes, and to investigate the mechanisms of insulin release. Methods. Oral glucose tolerance test was performed and plasma insulin levels were measured. Results. An oral treatment with GP (0.3 g/kg of body weight daily) for two weeks in GK rats improved glucose tole...

Journal: :The journal of physiological sciences : JPS 2008
E Brondum H Kold-Petersen H Nilsson A Flyvbjerg C Aalkjaer

UNLABELLED Type 2 diabetes is associated with many circulatory manifestations, including alteration in endothelial function and hypertension. In this study we investigate the morphology and contractile response as well as the endothelial function of resistance arteries from the spontaneously diabetic Goto-Kakizaki (GK) rat, a model of lean type 2 diabetes expressing glucose intolerance. METHO...

Journal: :Journal of virology 2005
Jeffrey M Melancon Rafael E Luna Timothy P Foster Konstantin G Kousoulas

Multiple amino acid changes within herpes simplex virus type 1 (HSV-1) gB and gK cause extensive virus-induced cell fusion and the formation of multinucleated cells (syncytia). Early reports established that syncytial mutations in gK could not cause cell-to-cell fusion in the absence of gB. To investigate the interdependence of gB, gK, and UL20p in virus-induced cell fusion and virion de-envelo...

Journal: :Acta biochimica et biophysica Sinica 2009
Bing Huang Wenming Qin Botao Zhao Yi Shi Chengguo Yao Jin Li Huasheng Xiao Youxin Jin

MicroRNAs (miRNAs), which are a newly identified class of small single-stranded non-coding RNAs, regulate their target genes via post-transcriptional pathway. It has been proved that miRNAs play important roles in many biological processes. To better understand miRNA function on type 2 diabetes, we used an oligonucleotide microarray to monitor miRNA expression profiles of Goto-Kakizaki (GK) and...

Journal: :Human molecular genetics 2004
Maki Inoue Yoshiyuki Sakuraba Hiromi Motegi Naoto Kubota Hideaki Toki Junko Matsui Yukiyasu Toyoda Ichitomo Miwa Yasuo Terauchi Takashi Kadowaki Yutaka Shigeyama Masato Kasuga Takashi Adachi Naomi Fujimoto Rie Matsumoto Keiko Tsuchihashi Tomoko Kagami Ayako Inoue Hideki Kaneda Junko Ishijima Hiroshi Masuya Tomohiro Suzuki Shigeharu Wakana Yoichi Gondo Osamu Minowa Toshihiko Shiroishi Tetsuo Noda

Mutant mouse models are indispensable tools for clarifying the functions of genes and for elucidating the underlying pathogenic mechanisms of human diseases. Currently, several large-scale mutagenesis projects that employ the chemical mutagen N-ethyl-N-nitrosourea (ENU) are underway worldwide. One specific aim of our ENU mutagenesis project is to generate diabetic mouse models. We screened 9375...

2011
Dr. Theodore

Charles River’s Disease Models program supports these efforts by making rodent models available for the study of cardiovascular, metabolic and renal diseases and their related complications. Additionally, through our Discovery and Imaging Services and Preclinical Services groups we have extensive experience using multiple models and species within these therapeutic areas. GK (Goto-Kakizaki) Rat...

1998
VIKAAS S. SOHAL CHARLES L. COX JOHN R. HUGUENARD John R. Huguenard

Sohal, Vikaas S., Charles L. Cox, and John R. Huguenard. changes, and the CCK8S response is blocked by the potasLocalization of CCK receptors in thalamic reticular neurons: a sium channel blocker Cs (Cox et al. 1995). However, voltmodeling study. J. Neurophysiol. 79: 2827–2831, 1998. In an age-clamp recordings in this study revealed a reversal potenearlier experimental study, intracellular reco...

Journal: :Public Health Forum 2022

Zusammenfassung Zur Bewältigung der COVID-19 Pandemie wird Gesundheitskompetenz (GK) Bevölkerung eine entscheidende Rolle zugeschrieben. Surveys zur Erfassung subjektiven bezogenen GK belegen unzureichende in Bevölkerung. Interventionen sollten diese stärken.

Journal: :American journal of physiology. Endocrinology and metabolism 2014
Kiichiro Ueta Tracy P O'Brien Gregory A McCoy Kuikwon Kim Erin C Healey Tiffany D Farmer E Patrick Donahue Audree B Condren Richard L Printz Masakazu Shiota

A loss of glucose effectiveness to suppress hepatic glucose production as well as increase hepatic glucose uptake and storage as glycogen is associated with a defective increase in glucose phosphorylation catalyzed by glucokinase (GK) in Zucker diabetic fatty (ZDF) rats. We extended these observations by investigating the role of persistent hyperglycemia (glucotoxicity) in the development of im...

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