نتایج جستجو برای: gk model
تعداد نتایج: 2106445 فیلتر نتایج به سال:
Hepatic glucokinase (GK) is acutely regulated by binding to its nuclear-anchored regulatory protein (GKRP). Although GK release by GKRP is tightly coupled to the rate of glycogen synthesis, the nature of this association is obscure. To gain insight into this coupling mechanism under physiological stimulating conditions in primary rat hepatocytes, we analyzed the subcellular distribution of GK a...
Aims. To evaluate the antidiabetic effects of Gynostemma pentaphyllum (GP) in Goto-Kakizaki (GK) rat, an animal model of type 2 diabetes, and to investigate the mechanisms of insulin release. Methods. Oral glucose tolerance test was performed and plasma insulin levels were measured. Results. An oral treatment with GP (0.3 g/kg of body weight daily) for two weeks in GK rats improved glucose tole...
UNLABELLED Type 2 diabetes is associated with many circulatory manifestations, including alteration in endothelial function and hypertension. In this study we investigate the morphology and contractile response as well as the endothelial function of resistance arteries from the spontaneously diabetic Goto-Kakizaki (GK) rat, a model of lean type 2 diabetes expressing glucose intolerance. METHO...
Multiple amino acid changes within herpes simplex virus type 1 (HSV-1) gB and gK cause extensive virus-induced cell fusion and the formation of multinucleated cells (syncytia). Early reports established that syncytial mutations in gK could not cause cell-to-cell fusion in the absence of gB. To investigate the interdependence of gB, gK, and UL20p in virus-induced cell fusion and virion de-envelo...
MicroRNAs (miRNAs), which are a newly identified class of small single-stranded non-coding RNAs, regulate their target genes via post-transcriptional pathway. It has been proved that miRNAs play important roles in many biological processes. To better understand miRNA function on type 2 diabetes, we used an oligonucleotide microarray to monitor miRNA expression profiles of Goto-Kakizaki (GK) and...
Mutant mouse models are indispensable tools for clarifying the functions of genes and for elucidating the underlying pathogenic mechanisms of human diseases. Currently, several large-scale mutagenesis projects that employ the chemical mutagen N-ethyl-N-nitrosourea (ENU) are underway worldwide. One specific aim of our ENU mutagenesis project is to generate diabetic mouse models. We screened 9375...
Charles River’s Disease Models program supports these efforts by making rodent models available for the study of cardiovascular, metabolic and renal diseases and their related complications. Additionally, through our Discovery and Imaging Services and Preclinical Services groups we have extensive experience using multiple models and species within these therapeutic areas. GK (Goto-Kakizaki) Rat...
Sohal, Vikaas S., Charles L. Cox, and John R. Huguenard. changes, and the CCK8S response is blocked by the potasLocalization of CCK receptors in thalamic reticular neurons: a sium channel blocker Cs (Cox et al. 1995). However, voltmodeling study. J. Neurophysiol. 79: 2827–2831, 1998. In an age-clamp recordings in this study revealed a reversal potenearlier experimental study, intracellular reco...
Zusammenfassung Zur Bewältigung der COVID-19 Pandemie wird Gesundheitskompetenz (GK) Bevölkerung eine entscheidende Rolle zugeschrieben. Surveys zur Erfassung subjektiven bezogenen GK belegen unzureichende in Bevölkerung. Interventionen sollten diese stärken.
A loss of glucose effectiveness to suppress hepatic glucose production as well as increase hepatic glucose uptake and storage as glycogen is associated with a defective increase in glucose phosphorylation catalyzed by glucokinase (GK) in Zucker diabetic fatty (ZDF) rats. We extended these observations by investigating the role of persistent hyperglycemia (glucotoxicity) in the development of im...
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