Ischemic/reperfusion brain injury (IRI) is a very severe event with the multiple etiopathogenesis. Ischemic preconditioning (IPC) is an important phenomenon of adaptation of CNS to subsequent ischemia. An altered cross-talk between intracellular calcium stores is presumed in the mechanisms of ischemic damage/protection. We show here that IRI leads to the inhibition of mitochondrial respiratory ...

As human populations grow, so do the resource demands imposed on ecosystems and the impacts of our global footprint. Natural resources are not invulnerable, nor infinitely available. The environmental impacts of anthropogenic actions are becoming more apparent – air and water quality are increasingly compromised, pests and diseases are extending beyond their historical boundaries, and deforesta...

In this study we evaluated whether administration of stem cells of neural origin (neural precursor cells, NPCs) could be protective against renal ischemia-reperfusion injury (IRI). We hypothesized that stem cell outcomes are not tissue-specific and that NPCs can improve tissue damage through paracrine mechanisms, especially due to immunomodulation. To this end, Wistar rats (200-250 g) were subm...

BACKGROUND Asthma control is suboptimal in Vietnam. Lack of knowledge of primary care physicians (PCPs) for asthma management may potentially be one of the causes. PURPOSE The aim of this study was to assess the knowledge and practice of PCPs' asthma management based on the Global Initiative for Asthma (GINA) guidelines (2015 update). METHODS A cross-sectional study with convenience samplin...

Background: MicroRNAs are important post-transcriptional regulators of gene expression, implicated in many physiological and pathophysiological processes, including kidney disease. Ischaemia reperfusion injury (IRI) is an inevitable consequence of transplantation and results in delayed graft function and primary non-function. The aim of this research was to characterise the role of microRNAs in...

A(2A) adenosine receptor (A(2A)R)-expressing bone marrow (BM)-derived cells contribute to the renal protective effect of A(2A) agonists in renal ischemia-reperfusion injury (IRI). We performed IRI in mice lacking T and B cells to determine whether A(2A)R expressed in CD4+ cells mediate protection from IRI. Rag-1 knockout (KO) mice were protected in comparison to wild-type (WT) mice when subject...

BACKGROUND AND PURPOSE Results regarding protective effects of dipeptidyl peptidase 4 (DPP4) inhibitors in renal ischaemia-reperfusion injury (IRI) are conflicting. Here we have compared structurally unrelated DPP4 inhibitors in a model of renal IRI. EXPERIMENTAL APPROACH IRI was induced in uninephrectomized male rats by renal artery clamping for 30 min. The sham group was uninephrectomized b...

Entrevista com Gina Vieira Ponte sobre praxiologias decoloniais.

Ischemia?reperfusion injury (IRI), also called reoxygenation injury, is the outcome of inflammatory processes and oxidative damage through induction stress. In clinical setting, IRI contributes to severe hepatic including liver cell death by apoptosis ferroptosis. Ferroptosis a novel type in that involves small molecules inhibit glutathione biosynthesis or peroxidase 4 (GPX4), which glutathione...