Although the giant cell tumor of bone is generally classified as a benign tumor it can rarely metastasize and has a potential risk of local recurrence. We want to report about a female patient who suffered from a recurrence of a giant cell tumor of bone after the implantation of a total endoprosthesis of the knee joint. We have treated her with denosumab, which is a receptor activator of nuclea...

INTRODUCTION: Almost 200 years ago, Sir Astley Cooper first described osteoclastomas, now called giant cell tumor of bone (GCT). GCTs is cited as the most aggressive benign tumor of the spine with unpredictable outcome. Although deemed benign, GCTs is reported to have tendency for significant bone destruction, local recurrence, and occasionally metastasis. It typically occurs in long bones and ...

Abstract Objects:Giant cell tumor of bone (GCTB) isa locally aggressive lesion with unpredictable behavior. Here, we aim to evaluate the epidemiological characteristics, clinical and functional outcome of GCTB in a relatively large series of patients. Methods:Patients with the diagnosis of GCTB were included in this retrospective study.Surgical options included extended curettage wh...

background: tumors involving the hand skeleton are rare. however, a basic knowledge of hand tumors is necessary for every clinician. this is due to the importance of distinguishing typical benign tumors from life or limb threatening malignant ones. methods: this study is a review of 99 cases of osseous hand tumors presented to the department of orthopedic surgery, imam khomeini hospital in tehr...