Signal transduction by the growth hormone receptor (GHR) occurs through growth hormone (GH)-induced dimerization of two GHRs to form a trimeric complex. It is thought that dimerization alone is sufficient for signaling, since monoclonal antibodies (mAbs) against the extracellular domain of the GHR elicit proliferation of FDC-P1 cells transfected with a chimeric receptor comprising the extracell...

We present a comprehensive survey of C II absorption detections toward stars within 100 pc in order to measure the distribution of electron densities present in the local interstellar medium (LISM). Using high spectral resolution observations of nearby stars obtained by the Goddard High-Resolution Spectrograph (GHRS) and the Space Telescope Imaging Spectrograph (STIS) onboard the Hubble Space T...

The endocrine system regulates growth mainly through the growth hormone (GH)/insulin-like growth factors (IGFs) axis and, although exercise promotes growth, little is known about its modulation of these factors. The aim of this work was to characterize the effects of 5 wk of moderate sustained swimming on the GH-IGFs axis in gilthead sea bream fingerlings. Plasma IGF-I/GH ratio and tissue gene ...

Short stature caused by biologically inactive growth hormone (GH) is characterized by lack of GH action despite high immunoassayable GH levels in serum and marked catch-up growth to exogenous GH administration. We found a heterozygous single-base substitution (A-->G) in exon 4 of the GH-1 gene of a girl with short stature, clinically suspected to indicate the presence of bioinactive GH and resu...

High resolution optical and ultraviolet spectra of two B-type post-Asymptotic Giant Branch (post-AGB) stars in globular clusters, Barnard29 in M13 and ROA5701 in ωCen, have been analysed using model atmosphere techniques. The optical spectra have been obtained with FEROS on the ESO 2.2-m telescope and the 2d-Coudé spectrograph on the 2.7-m McDonald telescope, while the ultraviolet observations ...

We have obtained spectra of three QSO/AGNs with the GHRS aboard the Hubble Space Telescope to search for absorption from low column density gas in the halo of the dwarf spheroidal (dSph) galaxy Leo I. The probe sightlines pass 2.1, 3.7, and 8.1 kpc from the center of the galaxy, but no C IV, Si II, or Si IV absorption is found at the velocity of Leo I. The absence of low ionization species sugg...

We report on GHRS observations which reveal conspicuous differences in the absorption spectra of two nearby stars, close to each other. The star HD102065 lies behind a cloud in Chamaeleon with unusually strong mid–IR emission, indicating a large abundance of very small dust particles. Along this line of sight, 5% of the gas (about 6 1019 cm−2) is at large velocities (up to -50 km s−1) compared ...

We present a new, high resolution HST/GHRS spectrum of quasar Q0302003, and use the He Lyman-α absorption, together with a high resolution Keck spectrum of the HI Lyman-α forest, to probe the distribution and ionization state of foreground gas just below the quasar redshift z ≈ 3.3. Within ≈ 4000 km/sec of the quasar redshift the spectrum shows a substantial flux (τ ≈ 1) with “He Lyman-α forest...

OBJECTIVE Circulating GH-binding protein (GHBP) is produced by proteolytical cleavage of the extracellular part of the GH receptor (GHR) and is positively correlated to the amount of body fat. To test the hypothesis that adipose tissue may contribute to the production of circulating GHBP, we compared gene expression of two GHR isoforms in adipose tissue with serum GHBP concentrations in healthy...

We observed the Seyfert 1 galaxy NGC 3516 with the Goddard High Resolution Spectrograph on the Hubble Space Telescope, and obtained UV spectra at a resolution of λ/∆λ ≈ 20,000 in the redshifted C IV λ1549 region. The intrinsic C IV absorption in the core of the broad emission line is resolved for the first time into four distinct kinematic components, which are all blue-shifted relative to the ...