Background Interleukin-15 (IL-15) mediates the function of some innate and adaptive immune cells, which makes it an attractive target as an anti-cancer agent. Gene electrotransfer (GET) has been used to safely deliver plasmid DNA (pDNA) to tissues in a number of pre-clinical and clinical studies for cancer therapy. Previously we have shown using GET to deliver interleukin-15 (IL-15) to mouse me...

The survival of microorganisms in ancient glacial ice and permafrost has been ascribed to their ability to persist in a dormant, metabolically inert state. An alternative possibility, supported by experimental data, is that microorganisms in frozen matrices are able to sustain a level of metabolic function that is sufficient for cellular repair and maintenance. To examine this experimentally, f...

A human immunodeficiency virus-negative male was successfully treated for two occurrences of Burkitt's lymphoma, 15 years apart. As consolidation of his second remission, he underwent high-dose chemotherapy with peripheral blood stem cell transplantation. In an effort to prove whether the second lymphoma was a relapse of the first or a second primary lymphoma, we obtained paraffin-embedded mate...

In this paper, we describe the participation of the Language Technologies Lab of INAOE at PAN 2015. According to the Author Profiling (AP) literature. In this paper we take such discriminative and descriptive information into a new higher level exploiting a combination of discriminative and descriptive representations. For this we use dimensionality reduction techniques on the top of typical di...

Aims. We study the uniformity of the distribution of compact flat-spectrum AGN on the sky and the evolution of their relativistic jets with cosmic epoch. Methods. A complete sample of compact extragalactic radio sources at 15 GHz was recently compiled to conduct the MOJAVE program. The MOJAVE sample comprises 133 radio-loud flat-spectrum AGN with compact relativistic outflows detected at parsec...

BACKGROUND A number of copy number variants (CNVs) have been suggested as susceptibility factors for schizophrenia. For some of these the data remain equivocal, and the frequency in individuals with schizophrenia is uncertain. AIMS To determine the contribution of CNVs at 15 schizophrenia-associated loci (a) using a large new data-set of patients with schizophrenia (n = 6882) and controls (n ...

Research on imitation in infancy has primarily focused on what and when infants imitate. More recently, however, the question why infants imitate has received renewed attention, partly motivated by the finding that infants sometimes selectively imitate the actions of others and sometimes faithfully imitate, or overimitate, the actions of others. The present study evaluates the hypothesis that t...

We present galaxy counts at 15 microns using the Japanese AKARI satelitte’s NEP-deep and NEP-wide legacy surveys at the north ecliptic pole. The total number of sources detected are approximately 6700 and 10 700 down to limiting fluxes of 117 and 250 microJy (5 sigma) for the NEP-deep and NEP-wide survey respectively. We construct the Euclidean normalized differential source counts for both dat...

This article offers a review of welfare reform evaluation studies, summarizing research that has generated a consensus among mainstream policy analysts that the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (PRWORA) has had few effects beyond caseload reductions and increases in employment. Given that supporters and opponents alike expected the law to have profound con...

readily accessible At a Glance box. Our goal is to communicate new knowledge effectively to ensure clinical benefit for people at risk for, living with, and surviving cancer. WeaimforJAMAOncology tobea forumfordiscussionboth nationally and internationally. GeorgeW. Sledge, Jr,MD,manages our Viewpoint articles, which address timely and controversial topics that affect clinical practice and the l...