Administration of GH-releasing peptide-2 (GHRP-2) represents a potential mode of therapy for children of short stature with inadequate secretion of GH. Requisite information to determine the dosing route and frequency for GHRP-2 consists of the pharmacokinetics (PK) and pharmacodynamics (PD) for this compound, neither of which have been previously evaluated in children. The purpose of this stud...

CONTEXT AND OBJECTIVE Alteration of exon splice enhancers (ESE) may cause autosomal dominant GH deficiency (IGHD II). Disruption analysis of a (GAA) (n) ESE motif within exon 3 by introducing single-base mutations has shown that single nucleotide mutations within ESE1 affect pre-mRNA splicing. DESIGN, SETTING, AND PATIENTS Confirming the laboratory-derived data, a heterozygous splice enhancer...

This study aimed to determine Bangkok chicken’sphenotypic characteristics and growth hormone genes using the PCR-RFLP method. The samples used were 50 chickens. Research in field is taking phenotypic traits data. laboratory carried out by DNA isolation, amplification, restriction. showed that DOC weight,body weight, bodyweight gain of DOC-1 month, 1-2 months, 2-3 months chickens significantly d...

BACKGROUND GnRH analogue (GnRHa) combined with GH treatment has been proposed to increase adult height. Effect on metabolic profile and GH, IGF1, and IGFBP3 levels in short small for gestational age (SGA) children is unknown. OBJECTIVE To assess fat mass and lean body mass SDS, percentage trunk fat, blood pressure (BP), insulin sensitivity (Si), beta-cell function (disposition index, DI), lip...

Plasma growth hormone (GH) levels were measured during the first 2 hours of sleep without electroencephalogram monitoring and then after arginine infusion in 28 children investigated for short stature. Ten children considered GH deficient on clinical and biochemical grounds had concordantly low GH levels during sleep and after arginine stimulation. Of the 18 children without GH deficiency, 17 h...

OBJECTIVE AND DESIGN Ageing and obesity result in decreased activity of the GH/IGF-I axis and concomitant impaired GH responses to secretory stimuli. We therefore determined the validity of the GH cut-off value of 15.0 microg/l in the GH-releasing hormone (GHRH)/GH releasing peptide-6 (GHRP-6) test for the diagnosis of GH deficiency in elderly or severely obese men. METHODS We performed a com...

OBJECTIVE The mammalian heart contains specific growth hormone-releasing peptide (GHRP) binding sites whose physiological significance is unknown. We sought to compare the effects of GHRP and GH on progressive left ventricular (LV) dysfunction in the TO-2 hamster model of dilated cardiomyopathy. METHODS TO-2 hamsters (8 weeks old) were injected with GHRP-6 (100 microg/kg day), GH (2 mg/kg day...

We reported a facile one-pot synthesis of bimetallic CoCu nanoparticles (NPs) anchored on graphene hydrogel (GH-CoCu) as catalysts in hydrogen generation from the hydrolysis ammonia borane (HAB). The presented novel method composed reduction mixture oxide, cobalt(II), and copper(II) acetate tetrahydrates by aqueous ethylene glycol solution teflon-coated stainless-steel reactor at 180 °C. struct...