PURPOSE Peptide drugs for antineoplastic therapies usually have low oral bioavailability and short in vivo half-lives, requiring less preferred delivery methods. Lanreotide depot is a sustained-release somatostatin analog (SSA) formulation produced via an innovative peptide self-assembly method. Lanreotide is approved in the USA and Europe to improve progression-free survival (PFS) in patients ...

PURPOSE The role of growth factors in ovarian cancer development and progression is complex and multifactorial. We hypothesized that new growth factors may be identified through the molecular analysis of ovarian tumors as they exist in their native environment. EXPERIMENTAL DESIGN RNA extracted from microdissected serous low malignant potential (LMP) and invasive ovarian tumors was used to co...

Quadratic eigenvalue problems (QEPs) appear in almost all vibration analysis of systems, such as buildings, circuits, acoustic structures, and so on. Conventional numerical method for QEPs is to linearize a QEP as a doublly-sized generalized eigenvalue problem (GEP), then call a backward stable algorithm to solve the GEP, for example, the QZ for dense GEP, and at last recover approximated eigen...

Different techniques are used to model the relationship between temperatures, dew point and relative humidity. Gene expression programming is capable of modelling complex realities with great accuracy, allowing at the same time, the extraction of knowledge from the evolved models compared to other learning algorithms. We aim to use Gene Expression Programming for modelling of dew point. General...

Correspondence to A.R. Moghassem email: [email protected] ABSTRACT This study compares capabilities of two different modelling methodologies for predicting breaking strength of rotor spun yarns. Forty eight yarn samples were produced considering variations in three drawing frame parameters namely break draft, delivery speed, and distance between back and middle rolls. Several topologies with dif...

A recently proposed paradigm suggests that, like their dietary counterparts, digestion of gastrointestinal endogenous proteins (GEP) may also produce bioactive peptides. With an aim to test this hypothesis, in vitro digests of four GEP namely; trypsin (TRYP), lysozyme (LYS), mucin (MUC), serum albumin (SA) and a dietary protein chicken albumin (CA) were screened for their angiotensin-I converti...

Introduction: Neuroendocrine tumors are a heterogeneous group of malignancies, characterised by production of hormones and vasoactive peptides. The incidence of gastroenteropancreatic neuroendocrine tumors (GEP-NET) is rising, and they have the highest prevalence amongst upper gastro-intestinal tumors. Diagnosis remains challenging due to wide variations in presentation and slow onset of sympto...

BACKGROUND Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare neuroendocrine tumors, and lack of data in Asian populations especially in China. The aim of this retrospective study was to assess the clinical, pathological and prognostic characteristics of GEP-NENs in China. METHODS We collected clinical and pathological data of 168 patients diagnosed with GEP-NENs and treated ...

In the current paper we present the application of our Gene Expression Programming Environment in forecasting Euro-United States Dollar exchange rate. Specifically, using the GEP Environment we tried to forecast the value of the exchange rate using its previous values. The data for the EUROUSD exchange rate are online available from the European Central Bank (ECB). The environment was developed...

A neuroendocrine neoplasm (nen) is a tumor that originates in neuroendocrine cells capable of producing peptides or amines. neuroendocrine neoplasms of the digestive system are also referred to as gastroenteropancreatic neuroendocrine neoplasms (GeP nen) and constitute a heterogeneous group of growths originating from at least 15 types of specialized cells spread throughout the stomach, small i...