نتایج جستجو برای: genotyping assay
تعداد نتایج: 242708 فیلتر نتایج به سال:
CYP2D6 contributes to the metabolism of many clinically used drugs and is increasingly tested to individualize drug therapy. The CYP2D6 gene is challenging to genotype due to the highly complex nature of its gene locus. TaqMan technology is widely used in the clinical and research settings for genotype analysis due to assay reliability, low cost, and the availability of commercially available a...
Running Title: Deep Sequencing-based HIV-1 Genotyping and Coreceptor Tropism Assay 5 6 7 Richard M. GIBSON , Ashley M. MEYER , Dane WINNER , John ARCHER , Felix FEYERTAG , 8 Ezequiel RUIZ-MATEOS , Manuel LEAL , David L. ROBERTSON , Christine L. SCHMOTZER , and 9 Miguel E. QUIÑONES-MATEU 1,4,* 10 11 1 University Hospital Translational Laboratory, University Hospitals Case Medical Center, Clevela...
Because of the enormous variability of hepatitis C virus (HCV), the development of reliable genotyping assays is a formidable challenge. The optimal genotyping region appears to be the 5' untranslated region (UR) because of high conservation within, but considerable variability between, genotypes. In this study, 21 probes dispersed over seven variable 5' UR areas were applied to a line probe as...
Genotyping variants in the human genome has proven to be an efficient method to identify genetic associations with phenotypes. The distribution of variants within families or populations can facilitate identification of the genetic factors of disease. Illumina's panel of genotyping BeadChips allows investigators to genotype thousands or millions of single nucleotide polymorphisms (SNPs) or to a...
The IL28B genotype is a critical determinant of interferon response in patients infected with hepatitis C virus genotype 1. We describe an allele-specific PCR assay for the IL28B genotype. The assay is simple and robust, uses commonly available real-time PCR instrumentation, and is well suited for clinical laboratories offering IL28B genotyping.
Genotyping experiments are widely used in clinical and basic research laboratories to identify associations between genetic variations and normal/abnormal phenotypes. Genotyping assay techniques vary from single genomic regions that are interrogated using PCR reactions to high throughput assays examining genome-wide sequence and structural variation. The resulting genotype data may include mill...
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