نتایج جستجو برای: genotypeenvironment interactions

تعداد نتایج: 387721  

2016
Mohamed N. Al-Arifi Syed Wajid Nawaf K. Al-Manie Faisal M. Al-Saker Salmeen D. Babelgaith Yousif A. Asiri Ibrahim Sales

OBJECTIVES To evaluate health care professionals' knowledge on warfarin interactions with drugs and herbs. METHODS A self-administered questionnaire was developed to assess health care professionals' knowledge on warfarin interactions with drug and herb. Respondents were asked to classify 15 drugs that may effect on warfarin action as "enhance", "inhibit ", "no effect". The study sample invol...

2015
BT Gufford JT Barr V González‐Pérez ME Layton JR White NH Oberlies MF Paine

Quantitative prediction of herb-drug interaction risk remains challenging. A quantitative framework to assess a potential interaction was used to evaluate a mechanism not previously tested in humans. The semipurified milk thistle product, silibinin, was selected as an exemplar herbal product inhibitor of raloxifene intestinal glucuronidation. Physiologically based pharmacokinetic (PBPK) model s...

2015
Mou-Ze Liu Yue-Li Zhang Mei-Zi Zeng Fa-Zhong He Zhi-Ying Luo Jian-Quan Luo Jia-Gen Wen Xiao-Ping Chen Hong-Hao Zhou Wei Zhang

The worldwide using of herb products and the increasing potential herb-drug interaction issue has raised enthusiasm on discovering the underlying mechanisms. Previous review indicated that the interactions may be mediated by metabolism enzymes and transporters in pharmacokinetic pathways. On the other hand, an increasing number of studies found that genetic variations showed some influence on h...

2005
Sam Shimomura Jack J. Chen

1 Identify the mechanism of grapefruit juice-drug interactions and drugs involved with significant grapefruit-drug interactions. 2 Describe potential effects of grapefruit juice-drug interactions.. 3 Discuss medications that may be affected and degree of risk associated with common interacting medications.. 4 Identify effective alternative medications that do not interact (for patients who do n...

2016
Hima Bindu Gujjarlamudi

There is an increase in population of elderly above the age of 65. As age advances, more diseases develop resulting in use of more medications. Physiological changes, alterations in homeostatic regulation and diseases modify pharmacokinetics and drug response in older patients. The risk for drug interactions and drug-related problems increases along with multiple medications. Periodic evaluatio...

2012
L Girard A Kutt C Necyk S Jasser B Law A Filipelli P Gardiner H Boon S Vohra

Purpose Individuals using herbal medicines concomitantly with prescription drugs are at risk of harms due to herb-drug interactions. As part of a prospective active surveillance study to identify natural health product harms, a tool to identify herb-drug interactions was created for clinician use. Such tools require regular updating to remain clinically relevant. Our objective was to review the...

2013
Bulus Adzu Kudirat Bola Mustapha Collen Masimirembwa Obiageri Obodozie Rukaiyatu Abdullahi Kirim Karniyus Shingu Gamaniel

OBJECTIVE To evaluate the effect of NIPRD-AM1 on CYP3A4 in order to generate clinically significant data for its safe and efficacious use. MATERIALS AND METHODS NIPRD-AM1 is a phytomedicine developed from aqueous root extracts of Nauclea latifolia Smith (Rubiaceae) for the treatment of uncomplicated malaria. The effect of NIPRD-AM1 on CYP3A4 was measured with and without the addition of NIPRD...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2014
Scott J Brantley Aneesh A Argikar Yvonne S Lin Swati Nagar Mary F Paine

Supported by a usage history that predates written records and the perception that "natural" ensures safety, herbal products have increasingly been incorporated into Western health care. Consumers often self-administer these products concomitantly with conventional medications without informing their health care provider(s). Such herb-drug combinations can produce untoward effects when the herb...

2017
Salih Kılıç Ahmet Çelik Hüseyin Altuğ Çakmak Abdülmecit Afşin Ahmet İlker Tekkeşin Gönül Açıksarı Mehmet Erdem Memetoğlu Fatma Özpamuk Karadeniz Ekrem Şahan Mehmet Hayri Alıcı Yüksel Dereli Ümit Yaşar Sinan Mehdi Zoghi

BACKGROUND The time in therapeutic range values may vary between different geographical regions of Turkey in patients vitamin K antagonist therapy. AIMS To evaluate the time in therapeutic range percentages, efficacy, safety and awareness of warfarin according to the different geographical regions in patients who participated in the WARFARIN-TR study (The Awareness, Efficacy, Safety and Time ...

2013
Jin GU Hai-Bin CHEN

Drug-drug interaction and herb-drug interaction have been frequently reported when patients take propofol in combination with other important clinical drugs or herbs. Intestinal bacteria-catalyzed biotransformation process might significantly change the properties of compounds, such as the efficiency, toxicity, and the pharmacokinetic behaviours. The present study aims to investigate whether th...

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