We investigated single nucleotide polymorphisms (SNP) at 87 sites of the phosphodiesterase 4D (PDE4D) gene in Mongol and Han patients with ischemic stroke in Inner Mongolia. SNPs in 226 patients with ischemic stroke (case group, 110 Mongol patients, 116 Han patients) and 220 patients without neurological disease (control group, 102 Mongol patients, 118 Han patients) were detected by polymerase ...

Organic cationic transporter 3 (OCT3, SLS22A3) has only recently emerged as one of the regulators of monoaminergic neurotransmission, which plays a critical role in the pathogenesis of depression and is a potential new antidepressant drug target. OCT3 single-nucleotide polymorphisms (SNPs) have been investigated for their association with psychiatric disorders such as methamphetamine use disord...

Iron overload has been noticed as a feature of human breast cancer. Cellular iron uptake is regulated by the hemochromatosis and transferrin receptor system, mutations of which cause the iron storage disease hereditary hemochromatosis. To understand the role of hemochromatosis and transferrin receptor system mutations in breast cancer, we analyzed 19 sequence variations at HFE, TFR1, TFR2, and ...

the aim of the study was to detect allelic and genotypic frequencies of a variants of betacasein (csn2) in Holstein cows and bulls in slovakia and to analyze milk production traits of tested cows in dependence on their csn2 genotypes. totally, 92 cows at the first parity and 5 bulls were tested. The samples were taken from cow’s vaginal smear and bull’s semen. DNA analyses were performed using ...

background host genetic and environmental factors are involved in development of gastric cancer. tumor necrosis factor (tnf)-î±| has a key role in helicobacter pylori -induced gastritis. we analyzed the association between tnf-î± polymorphism and the risk of gastric cancer in an iranian population residing in northeastern iran. materials and methods in a case-control study, the genotyping was c...

the cd1 family is less variable transmembrane antigen presenting molecules related to the mhc molecules. cd1a and cd1e genes are the most polymorphic ones associated with autoimmune diseases. the aim was to better clarify the map of cd1 genes in southwest iranian normal population for implications in vaccine design.in this study we investigated the polymorphism of cd1a, cd1d and cd1e in 311 hea...

In a recent paper by GILLESPIE and TURELLI (1 989), the authors suggest a model of genotype-environment interactions in which the contribution of a particular allele to a quantitative character depends on the environment. Based on this model, they come to the conclusion that such mechanism " may be a potent force maintaining genetic variation in quantitative characters. " The purpose of this no...

the broad goal of this research was to examine the nature of the melanocortin receptor 1 (mc1r) locus on the coat color phenotype of seven goat breeds with different color coat. blood samples were collected from five iranian indigenous (khalkhal, markhor, naeini, najdi and tali) and two exotic (cashmere and saanen) goat breeds. polymerase chain reaction restriction fragment length polymorphism ...

background: uterine leiomyoma (ul) is a benign tumor of uterine smooth muscle that affects women in reproductive ages. fas has an important role in initial stages of apoptosis. previous studies have shown an association between the fas gene and tumorigenesis. in the present study, we evaluated the relationship between fas a-670g (rs 1800682) and ul risk. methods: the fas gene polymorphism of 15...