BACKGROUND Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, being the primary cause of death from infection, especially if not recognized and treated promptly. The aim of this study was to analyze whether IL-6 rs1800795 polymorphism is associated with septic shock-related death in European white patients who underwent major surgery. METHODS W...

BACKGROUND & AIMS We performed a phase 2 trial of the efficacy and safety of 4, 6, and 8 weeks of sofosbuvir, given in combination with the NS5A inhibitor velpatasvir and the NS3/4A protease inhibitor GS-9857, in patients with hepatitis C virus (HCV) infection. METHODS We enrolled 161 treatment-naïve or previously treated patients infected with HCV genotypes 1 or 3 with or without compensated...

We evaluated the clinical efficacy of tailoring tacrolimus dosage to cytochrome P450 (CYP) 3A5 genotype in liver transplant patients. One hundred patients who received tacrolimus-based therapy were included in the retrospective study in which the relationship between the tacrolimus blood trough concentration/dosage ratio and the CYP3A5 genotype of both donors and recipients was determined. Subs...

The aim of the present study was to evaluate effect two dietary protein levels on performance, carcass characteristics, and meat quality parameters in fast- (Ross 308), medium- (JA757), slow-growing (ISA Dual) chickens assess interaction factors. Each genotype divided into a control group fed commercial type feed mixture an experimental low-protein diet (LP). trial terminated after common perio...

Recurrent respiratory papillomatosis is a disease cause by Human papillomavirus (HPV) characterized by the development of papillomas in the aero-digestiv tract. About 95% of the papilloma have laryngeal localization involving HPV genotypes 6 and 11 and the rest are distributed in the nasopharynx, oropharynx, lungs, bronchi and trachea. Our research consists of a prospective clinical study on 65...

Combination therapy with pegylated interferon alfa (PEG-IFN alfa) and the nucleoside analogue ribavirin is the current standard of care in patients infected with hepatitis C virus (HCV). Patients with HCV genotype 1 have a much less favorable response to therapy and are treated for 12 months, compared with patients infected with genotypes 2 and 3, in whom a 6-month course of therapy is sufficie...

During active disease, patients with systemic-onset juvenile chronic arthritis (S-JCA) demonstrate a rise and fall in serum interleukin-6 (IL-6) that parallels the classic quotidian fever. To investigate the possibility that this cytokine profile results from a difference in the control of IL-6 expression, we examined the 5 9 flanking region of the IL-6 gene for polymorphisms. A G/C polymorphis...

Background: The ACE (angiotensin-converting enzyme) gene is located on chromosome 17 and encodes a metallopeptidase dependent zinc (Zn) widely found the surface of endothelial epithelial cells. Objectives: This study compares relationship between enzyme activity I/D genotype in male female bodybuilders normal aerobic athletes. Methods: For this purpose, blood 200 people, who were divided into t...

INTRODUCTION Clinical samples from 433 patients pre-diagnosed with tuberculosis in Konya, Turkey, were investigated prospectively to compare the GenoType(®) MTBC test (GenoType(®) MTBC) with conventional "gold standard" culture methods. MATERIAL AND METHODS Lowenstein Jensen (LJ) and Mycobacteria Growth Indicator Tube (MGIT)-960 culture methods and GenoType(®) MTBC were performed together. ...