Both the number of cells and collective genome gut microbiota outnumber their mammalian hosts, metabolic physiological interactions with host have not yet been fully characterized. Cancer remains one leading causes death, more research into critical events that can lead to cancer importance be determined. The release microbial molecules simulate endogenous processes, such as inflammatory respon...

Common effluent treatment plant (CETP) is employed for treatment of tannery effluent. However, the performance of CETP for reducing the genotoxic substances from the raw effluent is not known. In this study, phytotoxic and genotoxic effects of tannery effluents were investigated in mung bean (Vigna radiata (L.) Wilczek). For this purpose, untreated and treated tannery effluents were collected f...

In our present study, different doses of allicin and L-ascorbic acid were tested against the genotoxic damage induced by chlormadinone acetate (CMA; 40 microM) using chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) as the parameters. Treatment with allicin and L-ascorbic acid resulted in reduction of CAs and SCEs. The results suggested a protective role of allicin and L-ascor...

Piperine and capsaicin are important molecules with biological pharmacological activities. This study aimed to evaluate the cytogenotoxic protective effect of piperine on Allium cepa cells. A. roots were exposed negative (2% Dimethylsulfoxide) positive (Methylmethanesulfonate, MMS, 10 µg/mL) controls, four concentrations (25-200 µM) or (alone) associated before, simultaneously after MMS. Only l...

This review document addresses the processes of DNA damage, repair and mutation as key steps on the pathway towards cancer development and also briefly describes the most common genotoxicity tests used in the evaluation of whether a compound is genotoxic or not. Knowledge that the carcinogen under evaluation is genotoxic or nongenotoxic is a vital stage of the risk assessment and influences the...

Hexavalent chromium (Cr [VI]) genotoxicity was studied using fish micronucleus analysis in peripheral blood erythrocytes from Pimephales promelas, the fathead minnow. Forty-five- to 60-d-old fish were used to assess the spontaneous level of genotoxic damage. The genotoxic effect of Cr (VI) obtained from potassium dichromate (K2Cr2O7) in tests performed for 7-, 14-, and 21-d exposure periods was...

AIMS The rapidly growing industrial and medical use of nanomaterials, especially zinc oxide and titanium dioxide, has led to growing concerns about their toxicity. Accordingly, the intrinsic genotoxic and cytotoxic potential of these nanoparticles have been evaluated. MATERIALS & METHODS Using a HEp-2 cell line, cytotoxicity was tested along with mitochondrial activity and neutral red uptake ...

Genotoxic assessment of landfill leachate before and after biological treatment was conducted with two human cell lines (Me45 and NHDF) and Daphnia magna somatic cells. The alkali version of comet assay was used to examine genotoxicity of leachate by DNA strand breaks analysis and its repair dynamics. The leachate samples were collected from Zabrze landfill, situated in the Upper Silesian Indus...

OBJECTIVE In the search of new human genotoxic biomarkers, the single cell gel electrophoresis assay has been proposed as a sensible alternative. MATERIAL AND METHODS This technique detects principally single strand breaks as well as alkali-labile and repair-retarded sites. RESULTS Herein we present our experience using the single cell gel electrophoresis assay in human population studies, ...