Genetic factors clearly cause Lewy-body Parkinson's disease (PD) in a subset of autosomal-dominant families. However, most cases of PD are sporadic. The two most likely models of four discussed for sporadic PD are the reduced penetrance model and the multifactorial model. Sporadic PD is likely to be caused by the combined effect of environmental precipitating factors and genetic susceptibility ...

On January 22-23, 1997, a workshop was held in Washington, D.C., under the auspices of the Division of Cancer Epidemiology and Genetics, National Cancer Institute (Bethesda, MD), and the Fred Hutchinson Cancer Research Center (Seattle, WA). The purpose of the workshop was to provide a forum for the discussion of the interplay between diet, genes, and cancer risk. This is just part of the burgeo...

"The darkest hour is just before dawn."

Urinary tract infections (UTI) are a common condition in children. Vesicoureteral reflux (VUR) represents a common associated condition with childhood UTI. UTI susceptibility appears to have a genetic component based on family and UTI cohort studies. Targeted analysis of innate immune system genetic variations indicate that these variations are important in UTI susceptibility. In this overview,...