Based on the kinetic model of genetic regulation system proposed by Am. J. Physiol. 274, c531 (1998)], the effects of fluctuations in the degradation reaction rate and the synthesis reaction rate of the transcription factor have been investigated through numerical computation and analysis theory. In the case of uncorrelated noises, it is shown that only the fluctuation of degradation reaction r...

Although serotonin is known to play an important role in pain processing, the relationship between the polymorphism in 5-HTTLPR and pain processing is not well understood. To examine the relationship more comprehensively, various factors of pain processing having putative associations with 5-HT functioning were studied, namely the subjective pain experience (pain threshold, rating of experiment...

We have recently developed analysis methods (GREML) to estimate the genetic variance of a complex trait/disease and the genetic correlation between two complex traits/diseases using genome-wide single nucleotide polymorphism (SNP) data in unrelated individuals. Here we use analytical derivations and simulations to quantify the sampling variance of the estimate of the proportion of phenotypic va...

Fitness distance correlation has been proposed as an analysis tool for the fitness function landscape of genetic algorithms. It has been shown that it works in some cases, but there are also counterexamples. We studied the fitness distance correlation and the optimal population size by two fitness functions with a translational minimum and with a meta-genetic algorithm. We discovered that the f...

The objective of this study was to estimates the genetic and environmental components for the lactation curve parameters, milk yield, age at first calving (AFC), calving interval (CI) and somatic cell count (SCC) in Iranian Holstein cows. The dataset consisted of 210625 test day records from 25883 cows with milk yield in the first parity recorded from July 2002 to September 2007 in a total of 9...

Widely used standard expressions for the sampling variance of intraclass correlations and genetic correlation coefficients were reviewed for small and large sample sizes. For the sampling variance of the intraclass correlation, it was shown by simulation that the commonly used expression, derived using a first-order Taylor series performs better than alternative expressions found in the literat...