This paper presents high speed and low power full adder cells designed with an alternative internal logic structure and Gate Diffusion Input (GDI) logic styles and hybrid CMOS logic style that lead to have a reduced Power Delay Product (PDP). The main design objective for this adder module is not only providing low-power dissipation and high speed but also full-voltage swing. In the first desig...

Power consumption and delay are two important considerations for VLSI systems which depend on various critical design parameters. The objective of this project is to reduce the power and to reduce the delay which increases the speed. The purpose of this paper is the design and implementation of an Arithmetic Logic Unit (ALU) using area optimizing techniques such as Gate Diffusion Input (GDI). I...

INTRODUCTION In children with cerebral palsy the abnormal activity of the rectus femoris (RF) during the swing phase results in "stiff-knee gait". Transferring the RF to a knee flexor tendon improves this stiffness. The effect may be limited by adhesions from scar tissue or from angular deviations along the surgically created muscle tendon route. HYPOTHESIS The goal of this study was to asses...

OBJECTIVE To identify gait patterns in a large group of children with diplegic cerebral palsy and to characterize each group according to age, Gross Motor Function Classification System (GMFCS) level, Gait Deviation Index (GDI) and previous surgical procedures. METHODS ONE THOUSAND EIGHT HUNDRED AND FIVE PATIENTS WERE DIVIDED IN SEVEN GROUPS REGARDING OBSERVED GAIT PATTERNS: jump knee, crouch...

Abstract This contribution examines the interpretation of Graph Derivative Indices (GDIs) from Quantum Mechanics (QM) perspective and its relation with Hückel molecular orbital (HMO) method. The different elements used for calculating Discrete Derivatives over atom-pairs are related to QM integrals appearing in Determinant. between Coulomb Resonance Integrals was estimated by topological way qu...

GoLoco ('Galpha(i/o)-Loco' interaction) motif proteins have recently been identified as novel GDIs (guanine nucleotide dissociation inhibitors) for heterotrimeric G-protein alpha subunits. G18 is a member of the mammalian GoLoco-motif gene family and was uncovered by analyses of human and mouse genomes for anonymous open-reading frames. The encoded G18 polypeptide is predicted to contain three ...

BACKGROUND The symptoms of numerous diseases result from genetic mutations that disrupt the homeostasis maintained by the appropriate integration of signaling gene activities. The relationships between signaling genes suggest avenues through which homeostasis can be restored and disease symptoms subsequently reduced. Specifically, disease symptoms caused by loss-of-function mutations in a parti...

GDP-bound prenylated Rabs, sequestered by GDI (GDP dissociation inhibitor) in the cytosol, are delivered to destined sub-cellular compartment and subsequently activated by GEFs (guanine nucleotide exchange factors) catalysing GDP-to-GTP exchange. The dissociation of GDI from Rabs is believed to require a GDF (GDI displacement factor). Only two RabGDFs, human PRA-1 and Legionella pneumophila Sid...

Rab is a family of small Ras-like GTPases regulating intracellular vesicle transport. We have previously reported that prenylated Rab acceptor or PRA1 interacts with Rab GTPases and vesicle-associated membrane protein (VAMP2). Structural prediction programs suggest that PRA1, with its two extensive hydrophobic domains, is likely to be an integral membrane protein. However, subcellular fractiona...