BACKGROUND Growth differentiation factor-15 (GDF-15) is a stress-responsive marker that might aid in the early diagnosis and risk stratification of patients with suspected acute myocardial infarction (AMI). METHODS In a prospective, international multicenter study, GDF-15, high-sensitivity cardiac troponin T (hs-cTnT), and B-type natriuretic peptide (BNP) were measured in 646 unselected patie...

Growth differentiating factor-15 (GDF-15), also known as macrophage inhibiting factor-1, is a member of the transforming growth factor-β superfamily, which has been implicated in cancer-associated weight loss. The present study investigated the association between cancer-associated weight loss and plasma GDF-15 concentration, as well as other biomarkers, in patients with metastatic lung or exoc...

INTRODUCTION During mammalian ovarian organogenesis, the massive loss of oogonia via apoptosis is attenuated by the association of germ cells with somatic mesoepithelial cells of the gonadal ridge to form primordial follicles. It is suspected that the germ cell actively participates in this process via the production of local regulatory factors. Growth differentiation factor-9 (GDF-9), a member...

Vascular pathology plays an important role in the development of cognitive decline and dementia. In this context, growth differentiation factor-15 (GDF-15) has been suggested to be a biomarker due to its regulatory roles in inflammatory and trophic responses during tissue injury. However, limited data exist on the associations of GDF-15 with either cerebrovascular disease (CeVD) burden or the s...

Abstract. Governance of natural resources is inherently complex and requires navigating trade-offs at multiple dimensions. In this paper, we present operationalize the “governance disruptions framework” (GDF) as a tool for holistic analysis resource governance systems. For each four dimensions framework (target adequacy, object instrument behavioural adequacy), formulate guiding questions to be...

Elevated natriuretic peptides provide strong prognostic information in patients with heart failure (HF). The role of novel biomarkers in HF needs to be established. Our objective was to evaluate the prognostic power of novel biomarkers, incremental to the N-terminal portion of the natriuretic peptide (NT-proBNP) in chronic HF. Concentrations of circulating NT-proBNP, growth differentiation fact...

Mitochondrial disorders (MD) comprise a group of heterogeneous clinical for which non-invasive diagnosis remains challenge. Two protein biomarkers have so far emerged MD detection, FGF-21 and GDF-15, but the identification additional capable improving their diagnostic accuracy is highly relevant. Previous studies identified Gelsolin as regulator cell survival adaptations triggered by mitochondr...

AIMS Growth differentiation factor-15 (GDF-15) predicts death and composite cardiovascular (CV) events in patients with acute coronary syndrome (ACS). We investigated the independent associations between GDF-15 levels and major bleeding, the extent of coronary lesions and individual CV events in patients with ACS. METHODS AND RESULTS Growth differentiation factor-15 was analysed at baseline (...

Growth differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15) play important functions in follicular and oocyte development in many species. This study evaluated the dynamic expression of GDF-9 and BMP-15 in canine follicles cells using flow cytometry analysis. Follicular cells were removed from three sizes of antral follicles (small, medium and large) from ovaries of bitch...

Severe acute pancreatitis (AP) is associated with high morbidity and mortality. Early severity stratification remains a challenging issue to overcome to improve outcomes. We aim to find novel plasma cytokines for the early identification of severe AP according to the revised Atlanta criteria.In this prospective observational study, 30 cytokines, screened semiquantitatively with a human multicyt...