RANULOCYTE colony-stimulating factor (G-CSF) is G a hematopoietic cytokine produced by monocytes, fibroblasts, and endothelial cells.’” G-CSF is known to have multiple functions in normal, steady-state hematopoiesis such as the regulation of neutrophil production and release from the bone marrow, neutrophil progenitor proliferation and differentiation, and the state of functional activation of ...

BACKGROUND The introduction of the first direct-acting antiviral agents (DAAs) for the treatment of hepatitis C virus (HCV), telaprevir and boceprevir, marked a unique event in which 2 disease-changing therapies received FDA approval at the same time. Comparative safety and effectiveness data in real-world populations upon which to make formulary decisions did not exist. OBJECTIVE To describe...

The v-src oncogene encodes a nonreceptor tyrosine kinase. When this gene was expressed in the myeloblastic cell line 32Dcl3, it was found to abrogate interleukin-3 (IL-3) dependence of this cell line and to block its ability to terminally differentiate into granulocytes in response to granulocyte colony-stimulating factor (GCSF). In contrast, a highly related tyrosine kinase gene, v-fgr, fails ...

Alemtuzumab (ALEM) is widely used as an induction therapy for organ transplantation, and numerous randomized controlled trials (RCTs) have been published to evaluate its efficacy and safety in kidney transplantation as compared with antithymocyte globulin (ATG). The purpose of this study was to compare the benefits and safety of ALEM with those of ATG for induction therapy.A systematic literatu...

Bone marrow-derived cells (BMDCs) are capable of migrating across the blood-brain barrier (BBB) and accumulating in the central nervous system (CNS) when transplanted into recipients conditioned with whole-body irradiation or chemotherapy. We used the chemotherapeutic agents busulfan and treosulfan to condition recipient mice for transplantation with bone marrow (BM) cells isolated from donor m...

An outbreak of pneumonia caused by a novel Coronavirus (2019-nCoV) is ongoing in China [1]. The disease 2019-nCoV was recently named as COVID-19 WHO. Although the case-fatality rate (about 2.3% up to now) lower than SARS, they share many similarities [2,3]. Early studies have shown that increased pro-inflammatory cytokines were associated with pulmonary inflammation and extensive lung damage SA...

Introduction: Febrile neutropenia (FN) is the most frequent complications reported during cytotoxic chemotherapy treatment. Granulocyte colony stimulating factor (GCSF) used to reduce and related complications. This study compares short versus long acting filgrastim for reduction of induced FN. Methods: Histologically confirmed solid cancer patients (n=112) receiving either high risk or interme...