The high-density gastroretentive dosage forms was made a theophylline tablets 250 mg by wet granulation method in three formulas with combine the polymer concentration. used sodium alginate and PVP K30, where 1st formula ratio of alginate: K30 (18.75%: 5%), 2nd 2, 5%) 3th (12.5%: 2.5%). third were evaluated weight uniformity test, size hardness drug content vitro release as well determination k...