Chagas' disease is an endemic infectious disease caused by a trypanosome prevalent in South America. An acute illness occurs in childhood (1) and, if the patient survives, an enlarged heart , dilated colon and megaesophagus (2) may develop 30 to 40 years later as manifestations of chronic Chagas' disease. The majority of those infected will always have a positive complement fixation test for tr...

Swallowing difficulties and constipation were included in the first description of Parkinsons ́s syndrome from 1817 (Parkinson 1817). Since then, numerous studies have confirmed the magnitude of symptoms and addressed their pathophysiology. In spite of this, much remains to be determined and treatment of gastrointestinal dysfunction in Parkinson ́s disease (PD) is often unsatisfactory. Parkinson ́...

1Department of Surgery, University of Alabama, Birmingham, AL 35233, USA 2Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada M5G 2M9 3Department of Surgery, Drexel University, Philadelphia, PA 19102, USA 4Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad 91967, Iran 5Department of Surgery, Massachusetts General Hospital, Boston, MA 02114...

Autistic disorder is a pervasive developmental disorder manifested in the first 3 years of life by dysfunction in social interaction and communication. Many efforts have been made to explore the biologic basis of this disorder, but the etiology remains unknown. Recent publications describing upper gastrointestinal abnormalities and ileocolitis have focused attention on gastrointestinal function...

• To get a global understanding of the pathophysiology of irritable bowel syndrome, idiopathic chronic constipation, and diverticular disease for a more rational use of dietary tools in these conditions; • To learn about the true impact of “food intolerance” on symptoms of irritable bowel, thereby gaining insight into the role of excluding selected food from the diet of these patients; • To kno...

A 22-year-old male presented with recurrent upper gastrointestinal bleeding along with pain in the abdomen. An upper gastrointestinal endoscopy revealed Menetrier’s disease affecting the body of the stomach, which was confirmed histopathologically [Figure 1]. There was hyperplasia of foveolar cells with elongation of the crypts, decrease in the number of gastric glands and mild lymphocytic infi...