a Division of Gastroenterology and Endocrinology, University Medical Center Rostock, Rostock, Germany, b Medical Clinic 1, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, c Department of General, Visceraland Vascular Surgery, Charité – University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany, d Medical Department (Gastroenterology, Infectious Diseases, Rheumato...

Affiliations: 1 Veterans Affairs Center for Clinical Management Research, Ann Arbor, MI, USA 2 Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, USA 3 Division of Gastroenterology, St Paul's Hospital, UBC, Vancouver, Canada 4 Departments of Family Medicine and Urology, University of Michigan Medical School, Ann Arbor, MI, USA 5 Division of Gastroenterology, McG...

Anna Sapone MD PhD, Celiac Center, Division of Gastroenterology Daniel A. Leffler MD, MS, Director of Clinical Research, Celiac Center, Director of Quality Improvement, Associate Professor of Medicine at Harvard Medical School, Division of Gastroenterology Rupa Mukherjee MD, Celiac Center, Division of Gastroenterology, Department of Medicine, Instructor in Medicine at Harvard Medical School, Be...

History and Clinical Signs Most colonic diseases cause overt signs of large bowel diarrhea, tenesmus, and/or dyschezia (e.g., painful defecation). Large bowel diarrhea is characterized by frequent (2–3 times normal) urges to defecate, with each bowel movement producing small volumes of feces that contain excessive mucus and sometimes fresh blood (e.g., hematochezia). Urgency may be seen with co...

Background: The incidence of microscopic colitis (MC) is increasing, but its etiology remains unknown. Case reports and limited controlled data suggest that commonly prescribed drugs may be triggers. The aim of this study was to evaluate the prevalence of selected medication use [Proton pump inhibitors (PPIs), HMG-CoA reductase inhibitors (statins), and Selective serotonin reuptake inhibitors (...

Therapy of Inflammatory Bowel Disease Crohn’s disease and ulcerative colitis cause significant morbidity in the pediatric age group. The precise etiology of inflammatory bowel disease remains unknown; therefore, our therapeutic efforts continue to be directed toward controlling the symptoms. Current therapy for inflammatory bowel disease is focused on the use of steroids because of their anti-i...

I will consider the literature on screening or surveillance for Barrett esophagus. In programs designed to screen for Barrett esophagus, members of the general population who are believed to be at increased risk (usually those with gastroesophageal reflux, although, as we will see, the at-risk population may be larger) undergo endoscopic evaluation once to establish or exclude the disease. Surv...

Humans rely on their gastrointestinal system for providing the body with a constant supply of nutrients, water and electrolytes. The food must be digested (reduced physically and chemically to a molecular level) to be absorbed in the small intestine. Since both digestion and absorption depend on diffusion the flow of nutrients along the small intestine (GI transit) must be compatible with the r...

Department of Gastroenterology, Tel Aviv Medical Centre, affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Department of Gastroenterology, Laniado Medical Centre, Netanya, Israel Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel Department of Interdisciplinary Endoscopy, University Hospital HamburgEppendorf, Hamburg, Germany Integrated Cance...

Yaming Liu,* Vikas K. Verma,* Harmeet Malhi, Greg J. Gores, Patrick S. Kamath, Arun Sanyal, Naga Chalasani, Bin Gao, and X Vijay H. Shah Division of Gastroenterology and Hepatology Mayo Clinic, Rochester, Minnesota; Division of Gastroenterology and Hepatology, Indiana University, Indianapolis, Indiana; Division of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, Virg...