The bone morphogenetic proteins, (BMP)s are regulatory peptides that have significant effects on the growth and differentiation of gastrointestinal tissues. In addition, the BMPs have been shown to exert anti-inflammatory actions in the gut and to negatively regulate the growth of gastric neoplasms. The role of BMP signaling in the regulation of gastric metaplasia, dysplasia and neoplasia has b...

Schwannomas, or neurinomas, are generally benign, slow-growing, asymptomatic neoplasms originating from the Schwann cells of a nerve sheath. As a part of spindle cell mesenchymal tumours, schwannomas arising from the gastrointestinal tract (GIT) are unusual; however, when they occur, the most common site involved is the stomach, which represents 0.2% of all gastric tumours. We report the case o...

Since the first description of H. pylori infection of the gastric mucosa by Warren and Marshall [1], the bacterium has progressively gained importance and, nowadays, it is recognized as the main pathogenetic factor in chronic gastritis, ulcer disease and gastric neoplasms. In recent years, there is increasing evidence of an association of H. pylori gastric infection with various extragastric di...

H YPOPROTEINEMIA occurs with greater frequency in patients with gastric cancer than in patients with other neoplasms or with benign lesions of the gastro-intestinal tract. This was noted earlier by various authors, and has been studied in this laboratory. Hypoproteinemia becomes more pronounced and resistant to therapy following surgical treatment for cancer of the stomach than following simila...

Gastric cancer is one of the most frequent neoplasms. Although the incidence of gastric cancer worldwide has declined, there is still high mortality. Treatment of inoperable disease is under evaluation in clinical trials. In palliative treatment chemotherapy containing cisplatin and 5-fluorouracil is the most widely used. In the past years progress in tumour biology has advanced greatly and has...

Cutaneous metastasis from gastric adenocarcinoma is uncommon, and the eyelid is a rare metastatic site. Three patterns of clinical presentation of eyelid metastasis have been described: nodular, infiltrative, and ulcerated. The infiltrative pattern, also known as an inflammatory diffuse pattern or mask-like metastasis, can be easily misdiagnosed as cellulitis or contact dermatitis. Here, we rep...

Endoscopic submucosal dissection (ESD) was developed for the en bloc resection of large early gastrointestinal neoplasms. A disadvantage of ESD is its technical difficulty, which requires advanced skills and is associated with a higher rate of complications. Endoscopic variceal obturation (EVO) using cyanoacrylate has emerged as the initial treatment of choice for acute gastric variceal bleedin...

Gastric cancer is one of the most common neoplasms and an important cause of cancer-related death worldwide. Efforts to reduce its high mortality rates are currently focused on multidisciplinary management. However, surgery remains a cornerstone in the management of patients with resectable disease. There is still some controversy as to the extent of lymph node dissection for potentially curabl...

Adenocarcinoma is the most common histological type of gastric tumour, accounting for approximately 95% of all gastric carcinomas. Gastrointestinal stromal tumours (GISTs) are rare mesenchymal neoplasms of the digestive tract. Synchronous adenocarcinoma and gastrointestinal stromal tumour (GIST) occurring in the stomach is rare and very few cases have been reported in literature. Synchronous tu...

The incidence of carcinoid tumors (CTs) has increased over time (1). Gender distribution is highly balanced –slightly higher in women for malignant carcinoids– and people of all ages are affected even if these tumors predominate during the sixth decade of life. Gastric carcinoids represent 3 per thousand of all gastric neoplasms. Reviews and series have been reported regarding gastric carcinoid...