There is growing use of anticancer complementary and alternative medicines (CAMs) worldwide. The purpose of the current study is to assess a sizeable variety of natural and plant sources of diverse origin, to ascertain prospective research directives for cancer treatment and potential new chemotherapy drug sources. In this study, 374 natural extracts (10 microg/mL-5 mg/mL) were evaluated for do...

PREMISE OF THE STUDY Microsatellite markers were developed for Garcinia paucinervis (Clusiaceae), an endangered and endemic tree species of karst habitats, to analyze its genetic diversity and genetic structure. METHODS AND RESULTS Using shotgun sequencing on an Illumina MiSeq platform, a total of 22 microsatellite primer sets were characterized, of which 17 were identified as polymorphic. Fo...

BACKGROUND Kolaviron, isolated from seeds of Garcinia kola, have been shown to possess wide pharmacological properties. PURPOSE The present study examined the effect of kolaviron on acetylcholinesterase activities in the hippocampus and striatum of adult Wistar rats. METHODS In this study, histological and histochemical methods were used to investigate the effects of kolaviron on the histol...

The effects of Garcinia kola (G. kola) seed extract on oestrous cycle, ovulation and foetal development were studied in adult female Sprague-Dawley (S-D) rats. Cyclic female rats weighing 150 to 200 g were divided into three experimental groups and a control group. Group 1 was fed with 200 mg/kg body weight of the extract on proestrous. Group 2 received 200 mg/kg body weight of the extract dail...

In recent decades, there has been increasing interest in the use of herbs to maintain human health, many growing in the Southern and Eastern Asian countries. One example, pericarps of Garcinia mangostana (GM), called mangosteen, have been in use for hundreds of years as a traditional herbal medicine for a variety of purposes, including treatment of skin infections and wounds (Mahabusarakam, 198...

Natural inhibitors of fatty acid synthase (FAS) are emerging as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Garcinia mangostana led to the isolation of 13 phenolic compounds (1-13) mainly including xanthone and benzophenone, in which compounds 7, 8, 9, 10, and 11 were isolated from this plant for the first time and compoun...

Mangosteen (Garcinia mangostana L.) is one of the most popular tropical fruits (called the "Queen of Fruits"), and is a rich source of oxygenated and prenylated xanthone derivatives. In the present work, phytochemical investigation has resulted in one new prenylated xanthone and 13 known xanthones isolated from the pericarp of G. mangostana. Their structures were established by spectroscopic da...

BACKGROUND Resistance of antimalarial drugs to Plasmodium falciparum has become a major concern in malaria eradication. Although it is also affected by several socioeconomic factors, a new antiplasmodial agent is needed for a global malaria control program. OBJECTIVE In this study, we attempted to uncover the antiplasmodial properties of Garcinia celebica, an Indonesian medicinal plant, along...