Cyberknife Radiosurgery – Overview Cyberknife technology is based on radiosurgical principles that have been in clinical practice for 30 years. Radiosurgery is the precise application of a high (tumour-destructing) dose of radiation in a precisely defined target volume, while protecting the surrounding healthy tissue. During radiosurgery, many radiation beams from different directions intersect...

BACKGROUND AND PURPOSE MR image-guided gamma knife radiosurgery is often used to treat intra-axial metastatic neoplasms. Following treatment, it is often difficult to determine whether a progressively enhancing lesion is due to metastatic tumor recurrence or radiation necrosis. The purpose of our study was to determine whether relative cerebral blood volume (rCBV), relative peak height (rPH), a...

The long-term outcome of gamma knife radiosurgery (GKS) for central neurocytomas remains unclear. In the present study, we retrospectively reviewed the medical records of 7 patients with 8 central neurocytomas who underwent GKS between March 1997 and April 2007. They were 3 men and 4 women age ranging 9 to 53 years old (mean 32.5 years old). The tumor volume at the time of GKS was 0.34-6.10 cm(...

Microsurgical resection, stereotactic radiosurgery (SRS), and conservative management are three methods of treatment for intracranial cavernomas. However if left untreated, cavernomas may lead to intracerebral hemorrhage, seizures, focal neurologic deficits, or headaches. Deciding how to manage a cavernoma patient depends on a multitude factors. While microsurgery is the standard treatment for ...

Radiosurgery is a surgical procedure associated with minimal functional morbidity and allows patients to return rapidly to their previous level of activity. Most tumors regress in volume with extended follow-up, and the rare occurrence of tumor growth after radiosurgery seems to occur early. Similarly, cranial neuropathy or other neurologic symptoms after irradiation occur within the first few ...

PURPOSE Stereotactic radiosurgery (SRS) is widely used for brain metastases but has been relatively contraindicated for large lesions (>3 cm). In the present study, we analyzed the efficacy and toxicity of hypofractionated Gamma Knife radiosurgery to treat metastatic brain tumors for which surgical resection were not considered as the primary treatment option. METHODS AND MATERIALS Thirty-six...

Purpose: The objective of this study is to report the combined experience at Johns Hopkins University (JHU) and the Miami Neuroscience Center (MNC) in treating brain metastases from melanoma with stereotactic radiosurgery (SRS). Methods and Materials: Prospectively collected clinical and demographic data on patients with melanoma treated with Gamma Knife (GK) at JHU between 2003 and 2007 and th...

Between May 1990, and June 1994, 79 patients with malignant tumors were treated radiosurgically using a Leksell gamma unit at Asan Medical Center. Of these patients, 57 were metastatic brain tumor, 12 were glioblastoma multiforme (GM), 4 were primitive neuroectodermal tumor, 3 were malignant germ cell tumor, 2 were recurrent lymphoma, and 1 was adenoid cystic carcinoma of the orbit. Among 57 pa...

Objective. Single-session radiosurgery with Gamma Knife (GK) may be a potential adjuvant treatment in acromegaly. We analyzed the safety and efficacy of GK in patients who had previously received maximal surgical debulking at our hospital. Methods. The study was a retrospective analysis of hormonal, radiological, and ophthalmologic data collected in a predefined protocol from 1994 to 2009. The ...