The gamma-secretase aspartyl protease is responsible for the cleavage of numerous type I integral membrane proteins, including amyloid precursor protein (APP) and Notch. APP cleavage contributes to the generation of toxic amyloid beta peptides in Alzheimer's disease, whereas cleavage of the Notch receptor is required for normal physiological signaling between differentiating cells. Mutagenesis ...

Gadolinium is a competent neutron conversion material for neutron detection due to its extremely high neutron capture cross section. It differs from the other neutron reactive materials by emitting large amounts of low-energy electrons for the consequent signal generation in a detector. Such low-energy electrons, though abundant, are prone to be contaminated by internal and/or external gamma ra...

JUNO is a multi-purpose neutrino experiment currently under construction in Jiangmen, China. It primary aiming to determine the mass ordering. Moreover, its 20\,kt target makes it an ideal detector study neutrinos from various sources, including nuclear reactors, Earth and atmosphere, Sun, even supernovae. Due small cross section of interactions, event rate experiments limited. In order maximiz...