نتایج جستجو برای: galectin 3

تعداد نتایج: 1813016  

2017
Ping Kei Yip Alejandro Carrillo-Jimenez Paul King Anna Vilalta Koji Nomura Chi Cheng Chau Alexander Michael Scott Egerton Zhuo-Hao Liu Ashray Jayaram Shetty Jordi L. Tremoleda Meirion Davies Tomas Deierborg John V. Priestley Guy Charles Brown Adina Teodora Michael-Titus Jose Luis Venero Miguel Angel Burguillos

Traumatic brain injury (TBI) is currently a major cause of morbidity and poor quality of life in Western society, with an estimate of 2.5 million people affected per year in Europe, indicating the need for advances in TBI treatment. Within the first 24 h after TBI, several inflammatory response factors become upregulated, including the lectin galectin-3. In this study, using a controlled cortic...

Journal: :Cancer research 1998
F Orlandi E Saggiorato G Pivano B Puligheddu A Termine S Cappia P De Giuli A Angeli

Galectin-3 is a carbohydrate-binding protein endowed with an affinity for beta-galactosides. It has been shown to play an important role in cell-cell and cell-matrix interactions and in pre-mRNA splicing. Furthermore, it is involved in the control of cell growth, neoplastic transformation, and metastasis. Interestingly, high levels of galectin-3 expression have been recently described in malign...

2015
Cho-Kai Wu Mao-Yuan Su Jen-Kuang Lee Fu-Tien Chiang Juey-Jen Hwang Jiunn-Lee Lin Jin-Jer Chen Fu-Tong Liu Chia-Ti Tsai

Heart failure with preserved ejection fraction (HFPEF) is characterized by myocardial interstitial fibrosis. A total of 146 patients with HFPEF, were recruited. HFPEF severity was determined using Doppler imaging (E/Em) and also cardiac magnetic resonance imaging (CMRI). Canine modeling of HFPEF was induced by aortic banding. Hemodynamic and echocardiographic data were obtained before and after...

2005
Mi-Hyoung Kim Hong-Gu Joo

Background: Dendritic cells (DCs) are the most potent APCs (antigen-presenting cells) and play a critical role in immune responses. Galectin-3 is a biological lectin with a beta-galactoside binding affinity. Recently, proteomic analysis revealed the presence of galectin-3 in the exosome of mature DCs. However, the expression and function of galectin-3 in DCs remains unclear yet. Methods: We use...

2016
Xiaoqian Qian Mingyang Li Mary B. Wagner Guangping Chen Xiang Song

Doxazosin, a drug commonly prescribed for hypertension and prostate disease, increases heart failure risk. However, the underlying mechanism remains unclear. Galectin-3 is an important mediator that plays a pathogenic role in cardiac hypertrophy and heart failure. In the present study, we investigated whether doxazosin could stimulate galectin-3 expression and collagen synthesis in cultured HL-...

2015
Carrie A. Duckworth Scott E. Guimond Paulina Sindrewicz Ashley J. Hughes Neil S. French Lu-Yun Lian Edwin A. Yates D. Mark Pritchard Jonathan M. Rhodes Jeremy E. Turnbull Lu-Gang Yu

Concentrations of circulating galectin-3, a metastasis promoter, are greatly increased in cancer patients. Here we show that 2- or 6-de-O-sulfated, N-acetylated heparin derivatives are galectin-3 binding inhibitors. These chemically modified heparin derivatives inhibited galectin-3-ligand binding and abolished galectin-3-mediated cancer cell-endothelial adhesion and angiogenesis. Unlike standar...

2017
Vanessa Arcolia Fabrice Journe Aurore Wattier Emmanuelle Leteurtre Florence Renaud Hans-Joachim Gabius Myriam Remmelink Christine Decaestecker Alexandra Rodriguez Sébastien Boutry Sophie Laurent Sven Saussez

Fine-needle aspiration (FNA) is the most commonly used pre-operative technique for diagnosis of malignant thyroid tumor. However, many benign lesions, with indeterminate diagnosis following FNA, are referred to surgery. Based on multifunctionality of the endogenous galectin-1, we aimed to assess its status for early diagnosis of thyroid cancer. Immunohistochemistry for galectin-1 and -3 was per...

2017
Laura Díaz-Alvarez Enrique Ortega

Galectins are a group of evolutionarily conserved proteins with the ability to bind β-galactosides through characteristic carbohydrate-recognition domains (CRD). Galectin-3 is structurally unique among all galectins as it contains a C-terminal CRD linked to an N-terminal protein-binding domain, being the only chimeric galectin. Galectin-3 participates in many functions, both intra- and extracel...

Journal: :International journal of molecular sciences 2016
Szu-Chia Chen Po-Lin Kuo

Galectin-3 is a 32- to 35-kDa member of the galectin family of b-galactoside-binding lectins, which is characterized by a carbohydrate recognition domain. Through its carbohydrate-binding function, it regulates cell growth, differentiation, and inflammation. It also plays a complex, context-dependent role in the kidneys. During development, it promotes nephrogenesis and is strongly expressed in...

Journal: :Circulation. Heart failure 2013
Robin A P Weir Colin J Petrie C Aengus Murphy Suzanne Clements Tracey Steedman Ashley M Miller Iain B McInnes Iain B Squire Leong L Ng Henry J Dargie John J V McMurray

BACKGROUND Galectin-3 is a biomarker associated with inflammation and fibrosis that predicts adverse outcome and relates to biomarkers of extracellular matrix turnover in patients with heart failure, particularly when left ventricular (LV) systolic function is preserved. Whether galectin-3 is related to LV remodeling after acute myocardial infarction is unknown. METHODS AND RESULTS Circulatin...

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