Mycobacterium tuberculosis is an extremely successful intracellular pathogen that has evolved a broad spectrum of pathogenic mechanisms that enable its manipulation of host defense elements and its survival in the hostile environment inside phagocytes. Cellular influx into the site of mycobacterial entry is mediated by a variety of chemokines, including interleukin-8 (IL-8), and the innate cyto...

objective(s): in the current study, the effects of selected folk medicinal herbs were evaluated in d-galactose-induced aging in male mice.   materials and methods: male balb/c mice were randomly divided into 12 groups composing sham, control, and treated groups. aging was induced by administration of d-galactose (500 mg/kg/day for 6 weeks). a positive control group was assigned that received vi...

The precise control of microRNA (miRNA) biosynthesis is crucial for gene regulation. Lin28A and Lin28B are selective inhibitors of biogenesis of let-7 miRNAs involved in development and tumorigenesis. Lin28A selectively inhibits let-7 biogenesis through cytoplasmic uridylation of precursor let-7 by TUT4 terminal uridyl transferase and subsequent degradation by Dis3l2 exonuclease. However, a rol...

this study was conducted to evaluate the effect of purslane hydro alcoholic extract on blood urea nitrogen (bun), creatinine (cr) and kidney histopathology of kidney aging model induced by d-galactose in female mice. in this experimental study, 72 female naval medical research institute (nmri) mice (30-35 g) were randomly divided into six groups including: control, purslane, d-galactose, d-gala...

The components of the uridine diphosphate galactose: lipopolysaccharide a-3-galactosyltransferase system from Salmonella iyphimurium were studied. Binary complexes (lipopolysaccharide-phospholipid) and ternary complexes (enzyme-lipopolysaccharide-phospholipid), previously postulated as intermediates in lipopolysaccharide biosynthesis, were reconstituted from the purified components. The complex...

and attendant exposure of the seaport town citizens to benzene emanating from petroleum handled through the terminal as one example, Goldstein reviewed a number of risk assessment issues. He noted that the risk assessment agenda has never been set by scientific experts but is always strongly affected by economic, political, and social issues. He also pointed out that there are two often contrad...

Although the mechanism of biosynthesis of homopolysaccharides, such as glycogen,' dextran,2 and starch,3 has been studied in some detail, relatively little attention has been given to the biosynthesis of the heteropolymeric mucopolysaccharides and lipopolysaccharides elaborated by animals and microorganisms. A promising approach to this problem has arisen out of recent work in several laborator...

In the present study a new economic and rapid bacterial micro-assay for simultaneous detection and quantitative measurement of serum galactose was developed. Analysis of the standard curve showed a linearity range for galactose from 2 mg/dL to 180 mg/dL with a regression equation of Y = 0.013X ? 0.083; R² = 0.962. The advantage of the method is its ability to measure serum galactose quantitativ...