نتایج جستجو برای: gadd45a
تعداد نتایج: 375 فیلتر نتایج به سال:
Abstract The interplay between T cells, dendritic cells and keratinocytes is crucial for the development maintenance of inflammation in psoriasis. GADD45 proteins mediate DNA repair different including keratinocytes. In immune system, GADD45a GADD45b regulate function activation both lymphocytes links epigenetic regulation through its demethylase activity. Here, we analyzed expression skin, cir...
The present study aims to investigate the role of p73 in response to cisplatin treatment in p53 wild-type neuroblastoma SH-SY5Y cells. Results showed that cisplatin induced a dose-dependent up-regulation of p53, p73, and a number of p53-responsive genes. Interestingly, endogenous Deltaexon2p73-expression was down-regulated by cisplatin treatment. Neither p21 nor GADD45 induction was observed in...
Human immunodeficiency virus type 1 (HIV-1) impacts multiple lineages of hematopoietic cells, including lymphocytes and macrophages, either by direct infection or indirectly by perturbations of cell networks, leading to generalized immune deficiency. We designed a study to discover, in primary human macrophages, sentinel genetic targets that are impacted during replication over the course of 7 ...
DNA methylation is a major epigenetic mechanism for gene silencing. Whereas methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions in mammalian genomes are protected from de novo methylation and whether an active demethylating activity is involved. Here, we show that either knockout or catalytic inactivation of the DNA repair enzyme thymine DNA glycosylase (T...
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