The high temperature dependence of junctionless (JL) gate-all-around (GAA) poly-Si thin-film transistors (TFTs) with 2-nm-thick nanosheet channel is compared with that of JL planar TFTs. The variation of SS with temperature for JL GAA TFTs is close to the theoretical value (0.2 mV/dec/K), owing to the oxidation process to form a 2-nm-thick channel. The bandgap of 1.35 eV in JL GAA TFTs by fitti...

We revisit Gaussian Adaptation (GaA), a black-box optimizer for discrete and continuous problems that has been developed in the late 1960’s. This largely neglected search heuristic shares several interesting features with the wellknown Covariance Matrix Adaptation Evolution Strategy (CMA-ES) and with Simulated Annealing (SA). GaA samples single candidate solutions from a multivariate normal dis...

BACKGROUND Disorders of creatine metabolism arise from genetic alterations of arginine:glycine amidinotransferase (AGAT), guanidinoacetate methyltransferase (GAMT), and the creatine transporter. We developed a strategy for the detection of AGAT and GAMT defects by measurement of guanidinoacetate (GAA) and creatine plus creatinine (Cr+Crn) in biological fluids. METHODS Three patients with AGAT...

BACKGROUND Most patients with Friedreich ataxia (FA) have a GAA trinucleotide repeat expansion in intron 1 of the FA gene (FRDA) on both arms of chromosome 9. However, some patients are compound heterozygotes and harbor a GAA expansion on one allele and a point mutation on the other. Compound heterozygous patients with FA who have a GAA expansion and a G130V mutation have been reported to have ...

Guanidinoacetic acid is formed from Arg and is the immediate precursor to creatine (Cre). A study was conducted to determine the ability for GAA to spare Arg in broiler chicks fed an Arg-deficient practical diet. A common basal diet (0.84% digestible Arg) was supplemented with combinations of Arg (0 or 0.16%) and GAA (0, 0.06, or 0.12%) to form a 2 × 3 factorial arrangement of dietary treatment...

Glycogen storage disease II (GSDII or Pompe disease, OMIM # 232300) is an autosomal recessive hereditary lysosomal disorder. Mutations in the GAA gene usually lead to reduced acid α-glucosidase (acid maltase, GAA, OMIM *606800, EC 3.1.26.2) activity, which results in impaired degradation and subsequent accumulation of glycogen within lysosomes. We present an Iranian boy, who was diagnosed with ...

Triplex structure-forming GAA/TTC repeats pose a dual threat to the eukaryotic genome integrity. Their potential to expand can lead to gene inactivation, the cause of Friedreich's ataxia disease in humans. In model systems, long GAA/TTC tracts also act as chromosomal fragile sites that can trigger gross chromosomal rearrangements. The mechanisms that regulate the metabolism of GAA/TTC repeats a...

28 29 Inadequate cervical cytological analysis can be facilitated by glacial acetic acid (GAA)-treatment 30 of primary liquid-based collections to remove mucus, erythrocytes, inflammatory cells, and 31 cellular debris. In the context of a commercial HPV hybridization assay performed on 465 32 tandem specimens with and without GAA treatment, we show that GAA treatment significantly 33 reduces ge...

A new optimization technique, called the Genetic Annealing Algorithm (GAA), is proposed in this paper to solve the task matching and scheduling problem in a heterogeneous computing system (HCS). Simple in design and easy to implement, the GAA employs only a stir operation, a novel idea based on the annealing concept, to locate optimal solutions for the problem. Extensive simulation runs have be...